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Gal-3 Protein Expression and Localization in Prostate Tumours

Gal-3 plays an important role in cell survival, mRNA splicing, and cell-cell and cell-matrix interactions. Depending on its cellular localization and cancer type, Gal-3 may have tumour-suppressive or tumour-promoting activities. Given the promising diagnostic role of Gal-3 in the urine of PCa patients found in our previous study, its concordant gene and protein expression levels, and its involvement in PCa-rela...

Adherence to oral therapeutic in patients with castrate-resistant metastatic pr...

Medication adherence is vital to the success of the treatment plan, being the priority of healthcare professionals to reduce the weak links that lead to medication errors and severe damage that they can cause. Based on the European profile of patients with castrate-resistant metastatic prostate cancer, the population under oral antineoplastic therapy for this pathology at Centro Hospitalar de Vila Nova de Gaia/...

Neuroendocrine Carcinoma and Intracystic Papillary Neoplasm: A Rare Association...

Neuroendocrine carcinoma of the gallbladder is a very rare neoplasia comprising only 0.2% of all the gastrointestinal neuroendocrine tumors. We present the case of an 85-year-old male with nonspecific gastrointestinal symptoms, progressive weight loss, and deterioration in the preceding 15 days. Imaging study showed a 5-cm polypoid mass localized at the gallbladder fundus, leading to a radical cholecystectomy. ...

Endoscopic Resection of a Rectal Neuroendocrine Tumor: Hybrid Endoscopic Submuc...

Large Pedunculated Lipoma of the Colon: Endoscopic Resection Using "Loop-and-Le...

Endoscopic Mucosal Resection with Circumferential Incision in Difficult Colorec...

Retroperitoneal Cellular Angiofibroma: A Rare Gynecological Entity

Cellular angiofibroma is a mesenchymal tumor, described in 1997, without gender preference, that usually appears at age 40. The vulvovaginal area is the most common site in women, mimicking vulvar benign tumors, like Bartholin gland cyst. However, there are a few described cases of a deep or extra-pelvic angiofibroma. Excision is the treatment of choice and the recurrence rate appears to be low. We present the ...

Intracystic Primary Squamous Cell Carcinoma of the Breast: A Challenging Diagnosis

We report a case of a 36-year-old woman that presented with a painful mass in the outer quadrants of the left breast that had grown rapidly. Physical examination revealed a well circumscribed elastic mass and breast ultrasound showed a cyst measuring 26 mm with vegetation growing on the inner wall. Microscopic evaluation, after fine needle aspiration cytology (FNAC), suggested benign lesion. Tumorectomy was per...