7 documents found, page 1 of 1
Vascular anatomy of L1 vertebral body in Wistar rat-corrosion-fluorescence, dia...
Moura, Diogo Lino; Casal, Diogo; Alves, Sara; Pinto, Dora; Novo, Maria; Almeida, Rui; Pais, Diogo; Casanova, José; Bernardes, AntónioCopyright © 2025 AME Publishing Company. All rights reserved.; BACKGROUND: The factors influencing bone healing in complete burst fractures-key to deciding between stabilization or vertebral replacement-remain poorly defined. Arterial vascularization and bone nutrition are known to affect healing or progression to necrosis. However, the role of vascular injury in vertebral fractures is not yet conclusively demo...
Chitosan-Based Membranes for Skin Wound Repair in a Dorsal Fold Chamber Rat Model
Casimiro, Maria Helena; Ferreira, Luís M.; Santos, Pedro M.P.; Leal, João P.; Rodrigues, Gabriela; Iria, Inês; Alves, Sara; Pais, Diogo; Casal, DiogoFunding Information: This research was funded by the International Atomic Energy Agency under Research Contract No. 18202 (CRP F23030). Authors acknowledge FCT—Fundação para a Ciência e a Tecnologia I.P. for the national funds in the scope of the project UIDB/04349/2020+UIDP/04349/2020, UIDB/00100/2020 and UIDB/00329/2020. Publisher Copyright: © 2022 by the authors.; Frequently, deep partial and full-thickness ...
Development of Dl1.72, a novel anti-DLL1 antibody with anti-tumor efficacy agai...
Silva, Gabriela; Sales-Dias, Joana; Casal, Diogo B.; Alves, Sara; Domenici, Giacomo; Barreto, Clara; Matos, Carolina; Lemos, Ana R.; Matias, Ana T.Funding Information: Funding: This research was funded by Fundação para a Ciência e Tecnologia, Portugal, grants PTDC/BBB-BMD/4497/2014 (to A.B.) and PD/BD/113987/2015 (to J.S.-D.), iBETXplore grants 3D-ABC-PI-717 (to G.D.) and BiACaT-HER2:JAG1 (to G.S.). iNOVA4Health—UIDB/04462/2020 and UIDP/04462/2020, a program financially supported by Fundação para a Ciência e Tecnolo-gia/Ministério da Ciência, Tecnologia e...
BD-2 and BD-3 increase skin flap survival in a model of ischemia and Pseudomona...
Casal, Diogo; Iria, Inês; Ramalho, José S.; Alves, Sara; Mota-Silva, Eduarda; Mascarenhas-Lemos, Luís; Pontinha, Carlos; Guadalupe-Cabral, MariaThe main aim of this work was to study the usefulness of human β-defensins 2 (BD-2) and 3 (BD-3), which are part of the innate immune system, in the treatment of infected ischemic skin flaps. We investigated the effect of transducing rat ischemic skin flaps with lentiviral vectors encoding human BD-2, BD-3, or both BD-2 and BD-3, to increase flap survival in the context of a P. aeruginosa infection associated w...
Reconstruction of a 10-mm-long median nerve gap in an ischemic environment usin...
Casal, Diogo; Mota-Silva, Eduarda; Iria, Inês; Alves, Sara; Farinho, Ana; Pen, Cláudia; Lourenço-Silva, Nuno; Mascarenhas-Lemos, LuísThe aim of this study was to evaluate in the Wistar rat the efficacy of various autologous nerve conduits with various forms of blood supply in reconstructing a 10-mm-long gap in the median nerve (MN) under conditions of local ischemia. A 10-mm-long median nerve defect was created in the right arm. A loose silicone tube was placed around the nerve gap zone, in order to simulate a local ischemic environment. Rat...
Blood Supply to the Integument of the Abdomen of the Rat
Casal, Diogo; Pais, Diogo; Iria, Inês; Videira, Paula A; Mota-Silva, Eduarda; Alves, Sara; Mascarenhas-Lemos, Luís; Pen, Cláudia; Vassilenko, ValentinaBACKGROUND: Many fundamental questions regarding the blood supply to the integument of the rat remain to be clarified, namely the degree of homology between rat and humans. The aim of this work was to characterize in detail the macro and microvascular blood supply to the integument covering the ventrolateral aspect of the abdominal wall of the rat. METHODS: Two hundred five Wistar male rats weighing 250-350 g w...
Optimization of an Arterialized Venous Fasciocutaneous Flap in the Abdomen of t...
Casal, Diogo; Mota-Silva, Eduarda; Pais, Diogo; Iria, Inês; Videira, Paula A.; Tanganho, David; Alves, Sara; Mascarenhas-Lemos, LuísBackground: Although numerous experimental models of arterialized venous flaps (AVFs) have been proposed, no single model has gained widespread acceptance. The main aim of this work was to evaluate the survival area of AVFs produced with different vascular constructs in the abdomen of the rat. Methods: Fifty-Three male rats were divided into 4 groups. In group I (n = 12), a 5-cm-long and 3-cm-wide conventional ...