3 documents found, page 1 of 1
The Barretos Cancer Hospital Animal Facility: implementation and results of a d...
Teixeira, Silvia A.; Luzzi, Mayara de Cassia; Martin, Ana Carolina Baptista Moreno; Duarte, Terence Teixeira; Leal, Mônica de OliveiraThe Barretos Cancer Hospital Animal Facility (BCHAF) is a unique facility in Brazil exclusively dedicated to working with animal models for cancer research. In this article, we briefly present our modern facility and the main experiments performed, focusing on mutant strains of mice (PTCH-knockout and <i>Apc<sup>Min</sup></i> mice), xenograft models, and patient-derived xenografts (PDXs). Our results show the p...
WNK2 inhibits autophagic flux in human glioblastoma cell line
Alves, Ana Laura Vieira; Costa, Angela Margarida; Martinho, Olga; da Silva, Vinicius Duval; Jordan, Peter; Silva, Viviane Aline Oliveira; Reis, R. M.Autophagy is a cell-survival pathway with dual role in tumorigenesis, promoting either tumor survival or tumor death. <i>WNK2</i> gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor gene in gliomas, regulating cell migration and invasion; however, its role in autophagy process is poorly explored. The <i>WNK2</i>-methylated human glioblastoma cell line A172 WT (wild type) was com...
WNK2 Inhibits Autophagic Flux in Human Glioblastoma Cell Line
Alves, Ana Laura Vieira; Costa, Angela Margarida; Martinho, Olga; da Silva, Vinicius Duval; Jordan, Peter; Silva, Viviane Aline OliveiraAutophagy is a cell-survival pathway with dual role in tumorigenesis, promoting either tumor survival or tumor death. WNK2 gene, a member of the WNK (with no lysine (K)) subfamily, acts as a tumor suppressor gene in gliomas, regulating cell migration and invasion; however, its role in autophagy process is poorly explored. The WNK2-methylated human glioblastoma cell line A172 WT (wild type) was compared to trans...