10 documents found, page 1 of 1
Determinação do mecanismo de ação citototóxica de alguns compostos extraídos de...
Pessoa, Cláudia do ÓEleven phytochemicals derived from plants to Northeast Brazil were studied for their antiproliferative effects in the human tumor cell lines CEM (leukemia) and SW-1573 (lung tumor), and in the normal human fibroblast cell line CCD-922. Using the MTT microtiter assay, five compounds were found to have IC50 values less than 10 gg/mL in the tumor cell lines. Jatrophone showed non-specifíc cytotoxicity, with IC50 v...
Preliminary in vitro evaluation of the anti-proliferative activity of guanylhyd...
França, Paulo H. B.; Silva-Júnior, Edeildo F. da; Aquino, Pedro G. V.; Santana, Antônio E. G.; Ferro, Jamylle N. S.; Barreto, Emiliano de OliveiraGuanylhydrazones have shown promising antitumor activity in preclinical tumor models in several studies. In this study, we aimed at evaluating the cytotoxic effect of a series of synthetic guanylhydrazones. Different human tumor cell lines, by including HCT-8 (colon carcinoma), MDA-MB-435 (melanoma) and SF-295 (glioblastoma) were continuous exposed to guanylhydrazone derivatives for 72 hours and growth inhibiti...
Phytochemical screening and evaluation of cytotoxicity of stem bark extracts of...
Pinheiro, Reísa da Silva; Rabelo, Suzana Vieira; Oliveira, Ana Paula de; Guimarães, Amanda Leite; Moraes Filho, Manoel Odorico dePurpose: To investigate the phytochemistry and cytotoxic activity of stem bark extracts from Anaxagorea dolichocarpa and Duguetia chrysocarpa - two species of the Annonaceae family. Methods: The crude ethanol bark extracts (EtOH) of the plants were obtained by maceration. The crude extracts were suspended in a mixture of methanol (MeOH) and water (H2O) (proportion 3:7 v/v) and partitioned with hexane, chlorofor...
Evaluation of the cytotoxicity of structurally correlated p-menthane derivatives
Andrade, Luciana Nalone; Lima, Tamires Cardoso; Amaral, Ricardo Guimarães; Pessoa, Cláudia do Ó; Moraes Filho, Manoel Odorico de; Soares, Bruno MarquesCompounds isolated from essential oils play an important role in the prevention and treatment of cancer. Monoterpenes are natural products, and the principal constituents of many essential oils. The aim of this study was to investigate the cytotoxic potential of p-menthane derivatives. Additionally, analogues of perillyl alcohol, a monoterpene with known anticancer activity, were evaluated to identify the molec...
Estudo fitoquímico, atividade antimicrobiana e citotóxica de espécimes de Leono...
Oliveira, Ana P.; Guimarães, Amanda L.; Pacheco, Alessandra G. M.; Araújo, Camila S.; Oliveira Júnior, Raimundo G.; Lavor, Érica M.; Silva, Mariana G.PHYTOCHEMICAL STUDY ON ANTIMICROBIAL AND CYTOTOXIC ACTIVITY OF SPECIMENS OF Leonotis nepetifolia L. R. (Br). Specimens of Leonotis nepetiflolia were obtained from cultivated and wild environments to verify their influences in chemical composition. Phytochemical analyses were conducted for the ethyl acetate phase obtained by partitioning the crude ethanol extract from the cultivated leaves of L. nepetifolia. In ...
Perfil de flavonoides e avaliação do potencial antioxidante e citotóxico de Bau...
Santos, Priscila Moraes dos; Almeida, Patrícia Danielle Oliveira de; Lima, Emerson Silva; Moraes Filho, Manoel Odorico de; Costa, Patrícia Marçal daBauhinia purpurea (Fabaceae). Plants of the Bauhinia species (Fabaceae) are used in the treatment of several infections and diseases, especially diabetes. In this paper, with an aim to contribute to the knowledge of the chemistry and therapeutic potential of the Amazonian species of the genus Bauhinia, flavonoid profiles in the leaves and branches of Bauhinia purpurea collected in Manaus and São Gabriel da Cach...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud, Talal Suleiman [UNESP]; Marques, Maria Rita; Pessoa, Cláudia do Ó; Lotufo, Leticia V. C.; Magalhães, Hemerson I. F.; Moraes, Manoel O. deSubmitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:57:49Z No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5); Made available in DSpace on 2013-08-22T18:57:49Z (GMT). No. of bitstreams: 1 S0102-695X2011000300017.pdf: 711209 bytes, checksum: 0aadb2d1954d80955d44caa2f22460cf (MD5) Previous issue date: 2011-06-01; Made availabl...
In vitro cytotoxic activity of Brazilian Middle West plant extracts
Mahmoud, Talal Suleiman; Marques, Maria Rita; Pessoa, Cláudia do Ó; Lotufo, Leticia Veras Costa; Magalhães, Hemerson Iury FerreiraABSTRACT - Cytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and the MTT method was used to detect the activit...
Synthesis and biological evaluation of new salicylate macrolactones from anacar...
Logrado, Lucio Paulo Lima; Silveira, Dâmaris; Romeiro, Luiz Antonio Soares; Moraes, Manoel Odorico de; Cavalcanti, Bruno CôelhoNo âmbito de uma linha de pesquisa que visa a obtenção de novas substâncias bioativas, a partir de lipídeos fenólicos não-isoprenóides de Anacardium occidentale, descrevemos a síntese e avaliação citotóxica de novas macrolactonas salicílicas, preparadas a partir da mistura de ácidos anacárdicos, principal constituinte do líquido da casca da castanha de caju (LCC) in natura.; In connection with our ongoing inves...
Constituintes químicos de Parmotrema lichexanthonicum Eliasaro & Adler - isolam...
Micheletti, Ana Carolina; Beatriz, Adilson; Lima, Dênis Pires de; Honda, Neli Kika; Pessoa, Cláudia do Ó; Moraes, Manoel Odorico deFrom the lichen Parmotrema lichexantonicum were isolated the depsidone salazinic acid, the xanthone lichexanthone, and the depside atranorin. The two major compounds, salazinic acid and lichexanthone, were selected for structure modifications. Salazinic acid afforded O-alkyl salazinic acids, some of them potentially cytotoxic against tumor cell lines (HCT-8, SF-295 and MDA/ MB - 435). From lichexanthone were ob...