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Candida albicans CUG mistranslation is a mechanism to create cell surface varia...

Miranda, Isabel; Silva-Dias, Ana; Rocha, Rita; Teixeira-Santos, Rita; Coelho, Carolina; Gonçalves, Teresa M.; Santos, Manuel A. S.; Pina-Vaz, Cidália

In the human fungal pathogen Candida albicans, the CUG codon is translated 97% of the time as serine and 3% of the time as leucine, which potentially originates an array of proteins resulting from the translation of a single gene. Genes encoding cell surface proteins are enriched in CUG codons; thus, CUG mistranslation may influence the interactions of the organism with the host. To investigate this, we compare...

Date: 2013   |   Origin: Estudo Geral - Universidade de Coimbra
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