6 documents found, page 1 of 1
Heparin Induced Thrombocytopenia In The Setting Of Urgent Cardiac Surgery: Can ...
Alves, Bárbara; Veiga, Joana; Morais, Inês; Lima, Fátima; Paulo, NelsonUnfractionated heparin is the main anticoagulant employed in the context of cardiovascular surgery. When a patient with heparin induced thrombocytopenia (HIT) is proposed for cardiac surgery, the anticoagulation management is challenging. Bivalirudin is an alternative to heparin in the perioperative setting. We present a rare case of a patient with HIT and cardiogenic shock that required bivalirudin use in the ...
PO 112 - Anesthetic implications of laparoscopy surgery in a patient with ventr...
Alves, Bárbara; Vieira, Lígia; Pereira, Cláudia; Silva, Carla; Assunção, José Pedrox
IL-6 induces the overexpression of genes involved in the regulation of apoptosi...
Alves, Bárbara; Pereira, Joana F.; Ferrão, José; Vieira, Luís; Matos, Paulo; Jordan, Peter; Gonçalves, VâniaIntroduction: An inflammatory microenvironment was identified as a critical tumor-promoting condition for cells harboring tumor-initiating mutations. Cancer cells respond to pro-inflammatory signals with changes in their transcriptome, namely upregulating the expression of pro-tumorigenic transcript variants. A paradigmatic example is the variant RAC1B. We found increased RAC1B levels in samples from inflammato...
Assessing the antitumor potential of variants of the extracellular carbohydrate...
Mota, Rita; Lima, Raquel T.; Flores, Carlos; Silva, Juliana F.; Cruz, Beatriz; Alves, Bárbara; Pinto, Marta T.; Adessi, Alessandra; Pereira, Sara B.Cancer is a leading cause of death worldwide with a huge societal and economic impact. Clinically effective and less expensive anticancer agents derived from natural sources can help to overcome limitations and negative side effects of chemotherapy and radiotherapy. Previously, we showed that the extracellular carbohydrate polymer of a Synechocystis ΔsigF overproducing mutant displayed a strong antitumor activi...
High VEGFA expression Is associated with improved progression-free survival aft...
Alves, Bárbara; Peixoto, Joana; Macedo, Sofia; Pinheiro, Jorge; Carvalho, Bruno; Soares, Paula; Lima, Jorge; Lima, Raquel T.Glioblastoma (GB) is a deadly tumor that demands for relevant biomarkers, particularly regarding patients’ response to treatment. MMP-2, MMP-9, VEGFA, and YKL40 are important molecules, given their implication in the infiltrative and angiogenic phenotype of GBs. The purpose of this study was to assess the relationship between the expression of MMP-2, MMP-9, VEGFA, and YKL40 in GB tissues and the patients’ respo...
Drug use in pregnant women of Mirandela, Macedo de Cavaleiros and Bragança
Branco, Ana Laura; Coutinho, Ana; Machado, Ana; Alves, Bárbara; Nascimento, Luís; Pereira, Olívia R.The use of drugs during the gestational period is a subject of great concern once the exposure of medicines may result in toxicities with possible irreversible lesions for fetus. In fact, drugs in pregnancy have been restricted since the accident of thalidomide. In 1979 the U.S. Food and Drug Administration (FDA) adopts the classification of drugs as the risk associated with their use during pregnancy, these be...