59 documents found, page 1 of 6
Comunicação eficaz na transição de cuidados de enfermagem no serviço de urgênci...
Alves, Cátia; Veiga-Branco , Maria AugustaIntrodução: A transferência de cuidados do doente, entre os profissionais responsáveis por ele, pode comprometer a sua segurança. Seja nas passagens de turno, ou transferências intra e inter-hospitalares. É essencial estabelecer uma comunicação eficaz, de modo a assegurar a fluidez de assunção de cuidados e responsabilidades. Estes pressupostos evitam a ocorrência de efeitos adversos, de eventuais atrasos no di...
Poly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer photo...
Alves, Cátia; Lima-Sousa, Rita; Melo, Bruna L.; Ferreira, Paula; Moreira, André; Correia, I.J.; de Melo-Diogo, DuarteConventional anticancer approaches are often associated with severe side effects. Herein, the authors assembled a novel nanoparticle whose therapeutic effect is triggered by laser light. In in vitro assays, the produced nanomaterial was able to, after interacting with laser light, reduce the viability of classic and advanced cancer models. In these conditions, but in the absence of laser light, no cytotoxicity ...
Sulfobetaine methacrylate-coated reduced graphene oxide-IR780 hybrid nanosystem...
Melo, Bruna L.; Lima-Sousa, Rita; Alves, Cátia; Correia, I.J.; de Melo-Diogo, DuarteNanomaterials with near infrared light absorption can mediate an antitumoral photothermal-photodynamic response that is weakly affected by cancer cells’ resistance mechanisms. Such nanosystems are commonly prepared by loading photosensitizers into nanomaterials displaying photothermal capacity, followed by functionalization to achieve biological compatibility. However, the translation of these multifunctional n...
Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial...
Lima-Sousa, Rita; Alves, Cátia; Melo, Bruna L.; Costa, Francisco J. P.; Nave, Micaela; Moreira, André F.; Mendonça, António; Correia, I.J.Progress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hi...
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT
Nave, Micaela; Costa, Francisco J. P.; Alves, Cátia; Sousa, Rita Lima; Melo, Bruna L.; Correia, I.J.; Diogo, Duarte de MeloNear infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomateri...
Multifunctional targeted solid lipid nanoparticles for combined photothermal th...
Granja, Andreia; Lima-Sousa, Rita; Alves, Cátia; de Melo-Diogo, Duarte; Nunes, Cláudia; Sousa, Célia T.; Correia, I.J.; Reis, SalettePhotothermal therapy has emerged as a new promising strategy for the management of cancer, either alone or combined with other therapeutics, such as chemotherapy. The use of nanoparticles for multimodal therapy can improve treatment performance and reduce drug doses and associated side effects. Here we propose the development of a novel multifunctional nanosystem based on solid lipid nanoparticles co-loaded wit...
Development of Thiol-Maleimide hydrogels incorporating graphene-based nanomater...
Costa, Francisco J. P.; Nave, Micaela; Sousa, Rita Lima; Alves, Cátia; Melo, Bruna L.; Correia, I.J.; Diogo, Duarte de MeloNano-sized materials have been widely explored in the biomedicine field, especially due to their ability to encapsulate drugs intended to be delivered to cancer cells. However, systemically administered nanomaterials face several barriers that can hinder their tumor-homing capacity. In this way, researchers are now focusing their efforts in developing technologies that can deliver the nanoparticles directly int...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
A transição/articulação da educação pré-escolar para o 1º ciclo do ensino básico
Alves, CátiaO presente relatório final de Mestrado em Educação Pré-Escolar e Ensino do 1º Ciclo do Ensino Básico teve como objetivo principal compreender se o processo de transição é atualmente realizado pelos profissionais de Educação (Educadores e Professores de 1º Ciclo do Ensino Básico) dos dois níveis de ensino, ou é um assunto meramente utópico. O ponto de partida do presente relatório teve início durante a realizaçã...
Chitosan-based injectable in situ forming hydrogels containing dopamine-reduced...
Melo, Bruna L.; Sousa, Rita Lima; Alves, Cátia; Moreira, André F.; Correia, I.J.; Diogo, Duarte de MeloStrategies combining nanomaterials’ chemotherapy and photothermal therapy hold an enormous potential for improving cancer treatment. Still, the translation of this modality has been hindered by the immunogenicity triggered by some of the polymers used for coating nanomaterials as well as by the nanostructures’ poor tumor uptake after systemic administration. To address this bottleneck, the formulation of inject...