Encontrados 61 documentos, a visualizar página 1 de 7
Plasma-treated bacterial nanocellulose-lignin composites for biomedical applica...
Alves, Cátia; Melro, Liliana Sofia Silva Ferreira Pinto; Fernandes, Marta; Padrão, Jorge; Moldes, Diego; Serra, Sofia Cravino; Salgado, A. J.Bacterial nanocellulose (BC) as a bioimplant possesses several limitations, encompassing absence of bioactivity, and unsatisfactory mechanical properties. Envisaging antimicrobial activity, enhanced cytocompatibility and mitigation of the inflammatory response, surface characteristics such as hydrophilicity and rugosity were tailored. Different strategies comprising treatments with Kraft lignin (KL), glycerin (...
Electrospun fibers loaded with extracts of Gunnera tinctoria and Buddleja globo...
Hermosilla, Jeyson; Alves, Cátia; Zille, Andrea; Padrão, Jorge; Sanhueza, Claudia; Pastene-Navarrete, Edgar; Acevedo, FranciscaThis study reports the development of electrospun polycaprolactone (PCL) fibers loaded with bioactive extracts of Gunnera tinctoria and Buddleja globosa for potential applications in wound healing. Plant extracts were obtained using green extraction methods (aqueous and hydroalcoholic) and characterized via FTIR, HPLC, and antioxidant assays. The G. tinctoria extract exhibited the highest total polyphenol conte...
Comunicação eficaz na transição de cuidados de enfermagem no serviço de urgênci...
Alves, Cátia; Veiga-Branco , Maria AugustaIntrodução: A transferência de cuidados do doente, entre os profissionais responsáveis por ele, pode comprometer a sua segurança. Seja nas passagens de turno, ou transferências intra e inter-hospitalares. É essencial estabelecer uma comunicação eficaz, de modo a assegurar a fluidez de assunção de cuidados e responsabilidades. Estes pressupostos evitam a ocorrência de efeitos adversos, de eventuais atrasos no di...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
Development of Thiol-Maleimide hydrogels incorporating graphene-based nanomater...
Costa, Francisco J. P.; Nave, Micaela; Sousa, Rita Lima; Alves, Cátia; Melo, Bruna L.; Correia, I.J.; Diogo, Duarte de MeloNano-sized materials have been widely explored in the biomedicine field, especially due to their ability to encapsulate drugs intended to be delivered to cancer cells. However, systemically administered nanomaterials face several barriers that can hinder their tumor-homing capacity. In this way, researchers are now focusing their efforts in developing technologies that can deliver the nanoparticles directly int...
Injectable hydrogels for the delivery of nanomaterials for cancer combinatorial...
Lima-Sousa, Rita; Alves, Cátia; Melo, Bruna L.; Costa, Francisco J. P.; Nave, Micaela; Moreira, André F.; Mendonça, António; Correia, I.J.Progress in the nanotechnology field has led to the development of a new class of materials capable of producing a temperature increase triggered by near infrared light. These photothermal nanostructures have been extensively explored in the ablation of cancer cells. Nevertheless, the available data in the literature have exposed that systemically administered nanomaterials have a poor tumor-homing capacity, hi...
Simple preparation of POxylated nanomaterials for cancer chemo-PDT/PTT
Nave, Micaela; Costa, Francisco J. P.; Alves, Cátia; Sousa, Rita Lima; Melo, Bruna L.; Correia, I.J.; Diogo, Duarte de MeloNear infrared (NIR) light-responsive nanomaterials hold potential to mediate combinatorial therapies targeting several cancer hallmarks. When irradiated, these nanomaterials produce reactive oxygen species (photodynamic therapy) and/or a temperature increase (photothermal therapy). These events can damage cancer cells and trigger the release of drugs from the nanomaterials’ core. However, engineering nanomateri...
Sulfobetaine methacrylate-coated reduced graphene oxide-IR780 hybrid nanosystem...
Melo, Bruna L.; Lima-Sousa, Rita; Alves, Cátia; Correia, I.J.; de Melo-Diogo, DuarteNanomaterials with near infrared light absorption can mediate an antitumoral photothermal-photodynamic response that is weakly affected by cancer cells’ resistance mechanisms. Such nanosystems are commonly prepared by loading photosensitizers into nanomaterials displaying photothermal capacity, followed by functionalization to achieve biological compatibility. However, the translation of these multifunctional n...
Multifunctional targeted solid lipid nanoparticles for combined photothermal th...
Granja, Andreia; Lima-Sousa, Rita; Alves, Cátia; de Melo-Diogo, Duarte; Nunes, Cláudia; Sousa, Célia T.; Correia, I.J.; Reis, SalettePhotothermal therapy has emerged as a new promising strategy for the management of cancer, either alone or combined with other therapeutics, such as chemotherapy. The use of nanoparticles for multimodal therapy can improve treatment performance and reduce drug doses and associated side effects. Here we propose the development of a novel multifunctional nanosystem based on solid lipid nanoparticles co-loaded wit...
Poly(2-ethyl-2-oxazoline)–IR780 conjugate nanoparticles for breast cancer photo...
Alves, Cátia; Lima-Sousa, Rita; Melo, Bruna L.; Ferreira, Paula; Moreira, André; Correia, I.J.; de Melo-Diogo, DuarteConventional anticancer approaches are often associated with severe side effects. Herein, the authors assembled a novel nanoparticle whose therapeutic effect is triggered by laser light. In in vitro assays, the produced nanomaterial was able to, after interacting with laser light, reduce the viability of classic and advanced cancer models. In these conditions, but in the absence of laser light, no cytotoxicity ...