4 documents found, page 1 of 1
TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to...
Rego, Inês Ramos; Silvério, Daniela; Eufrásio, Maria Isabel; Pinhanços, Sandra Sofia; Lopes da Costa, Bruna; Teixeira, José; Fernandes, Hugo; Kong, YangAge-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progression of AMD and results from the excessive accumulation of reactive oxygen species (ROS) produced mainly by mitochondria. Tumor necrosis factor receptor-associated...
PINK1/PARKIN signalling in neurodegeneration and neuroinflammation
Quinn, Peter M. J.; Moreira, Paula I.; Ambrósio, António Francisco; Alves, C. HenriqueMutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous mitochondria, thus fine-tuning mitochondrial network and preserving energy metabolism. PINK1 regulates PARKIN transloca...
Crumbs2 mediates ventricular layer remodelling to form the spinal cord central ...
Tait, Christine M.; Chinnaiya, Kavitha; Manning, Elizabeth; Murtaza, Mariyam; Ashton, John-Paul; Furley, Nicholas; Hill, Chris J.; Alves, C. HenriqueIn the spinal cord, the central canal forms through a poorly understood process termed dorsal collapse that involves attrition and remodelling of pseudostratified ventricular layer (VL) cells. Here, we use mouse and chick models to show that dorsal ventricular layer (dVL) cells adjacent to dorsal midline Nestin(+) radial glia (dmNes+RG) down-regulate apical polarity proteins, including Crumbs2 (CRB2) and delami...
From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Der...
Alves, C. Henrique; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Alpoim, Maria C.; Botana, Luis M.; Pedrosa, RuiMarine environment has demonstrated to be an interesting source of compounds with uncommon and unique chemical features on which the molecular modeling and chemical synthesis of new drugs can be based with greater efficacy and specificity for the therapeutics. Cancer is a growing public health threat, and despite the advances in biomedical research and technology, there is an urgent need for the development of ...