6 documents found, page 1 of 1
Nociceptive mechanisms driving pain in a post-traumatic osteoarthritis mouse model
Alves, CJ; Couto, M; Sousa, DM; Magalhães, A; Neto, E; Leitão, L; Conceição, F; Monteiro, AC; Ribeiro-da-Silva, M; Lamghari, MIn osteoarthritis (OA), pain is the dominant clinical symptom, yet the therapeutic approaches remain inadequate. The knowledge of the nociceptive mechanisms in OA, which will allow to develop effective therapies for OA pain, is of utmost need. In this study, we investigated the nociceptive mechanisms involved in post-traumatic OA pain, using the destabilization of the medial meniscus (DMM) mouse model. Our resu...
Early-life stress affects drug abuse susceptibility in adolescent rat model ind...
Alves, RL; Oliveira, P; Lopes, IM; Portugal, CC; Alves, CJ; Barbosa, F; Summavielle, T; Magalhães, AThe development of substance abuse problems occurs due to a diverse combination of risk factors. Among these risks, studies have reported depression and early-life stress as of importance. These two factors often occur simultaneously, however, there is a lack of understanding of how their combined effect may impact vulnerability to drug abuse in adolescence. The present study used rats with different vulnerabil...
The Mechanisms Underlying the Biological Response to Wear Debris in Periprosthe...
Couto, M; Vasconcelos, DP; Sousa, DM; Sousa, B; Conceição, F; Neto, E; Lamghari, M; Alves, CJJoint replacement surgery is the gold-standard therapeutic approach to treat patients with end-stage hip and knee arthritis, providing pain relief and joint function recovery. Despite the improvements in implant design and surgical techniques, revisions after total joint replacement are expected to grow. The periprosthetic inflammation, featured by the sustained inflammatory response to the implant debris, elic...
Osteoblasts are inherently programmed to repel sensory innervation
Leitão, L; Neto, E; Conceição, F; Monteiro, AC; Couto, M; Alves, CJ; Sousa, DM; Lamghari, MTissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons. Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development. Yet, the current understanding of the mechanisms regulating the map of sensory innervation in th...
Interplay between sympathetic nervous system and inflammation in aseptic loosen...
Ribeiro da Silva, M.; Vasconcelos, DM; Alencastre, IS; Oliveira, MJ; Linhares, D; Neves, N; Costa, G; Henrique, R; Lamghari, M; Alves, CJInflammation is a common symptom in joint disorders such as rheumatoid arthritis, osteoarthritis (OA) and implant aseptic loosening (AL). The sympathetic nervous system is well known to play a critical role in regulating inflammatory conditions, and imbalanced sympathetic activity has been observed in rheumatoid arthritis. In AL it is not clear whether the sympathetic nervous system is altered. In this study we...
Interplay between sympathetic nervous system and inflammation in aseptic loosen...
Ribeiro-da-Silva, M; Vasconcelos, DM; Alencastre, IS; Oliveira, MJ; Linhares, D; Neves, N; Costa, G; Henrique, R; Lamghari, M; Alves, CJInflammation is a common symptom in joint disorders such as rheumatoid arthritis, osteoarthritis (OA) and implant aseptic loosening (AL). The sympathetic nervous system is well known to play a critical role in regulating inflammatory conditions, and imbalanced sympathetic activity has been observed in rheumatoid arthritis. In AL it is not clear whether the sympathetic nervous system is altered. In this study we...