71 documents found, page 1 of 8
Synthesis, Characterization, and Biological Effects of Chloro-Cathinones: Toxic...
Gomes, Ana Patrícia; Ferro, Raquel; Pinto, Daniela; Silva, Joana; Alves, Celso; Pacheco, Rita; Gaspar, HelenaCathinones, a class of synthetic new psychoactive substances (NPSs), continue to emerge and pose public threats. Government control efforts often lead to the emergence of new isomers, which have adverse repercussions on NPSs identification and risk prediction. This work reports on the synthesis and structural characterization of twenty chloro-cathinones, including different isomers, to create analytical data to...
Marine Natural Products as Anticancer Agents 3.0
Alves, Celso; Diederich, MarcCancer represents a major global health challenge[...]
Chemical Characterization and Bio-Screening of Neuroprotective Potential of Bra...
dos Santos, Thalisia Cunha; Obando, Johana Marcela Concha; Silva, Joana; Santos, Ana Luíza Vidal Pimentel; Martins, Roberto Carlos CamposBrazilian native seaweed Canistrocarpus cervicornis (Ochrophyta, Dictyotaceae) is recognized for its chemodiversity, particularly cyclic diterpenes and polysaccharides, yet its relevance to neurological disorders remains unexplored. This study evaluated the neuroprotective potential of a hydroethanolic extract (ECCH), its polar fraction (CCFPol), a dichloromethane extract (ECCD), and eight derived fractions (CC...
Relatório de Estágio Curricular – Publiserv (Peso da Régua)
Alves, CelsoEste relatório surge no seguimento da realização de um estágio curricular, que faz parte do plano curricular da licenciatura em marketing no Instituto Politécnico da Guarda. O estágio foi realizado dentro das estruturas empresariais da Publiserv, com sede na cidade Peso da Régua. A Publiserv é uma empresa com mais de 15 anos de experiência e trabalha no ramo da publicidade e serviços de marketing tradicional. O...
Sulfated polysaccharides from macroalgae: A simple roadmap for chemical charact...
Martins, Alice; Alves, Celso; Silva, Joana; Pinteus, Susete; Gaspar, Helena; Pedrosa, RuiThe marine environment presents itself as a treasure chest, full of a vast diversity of organisms yet to be explored. Among these organisms, macroalgae stand out as a major source of natural products due to their nature as primary producers and relevance in the sustainability of marine ecosystems. Sulfated polysaccharides (SPs) are a group of polymers biosynthesized by macroalgae, making up part of their cell w...
New insights into the dermocosmetic potential of the red seaweed Gelidium corneum
Matias, Margarida; Martins, Alice; Alves, Celso; Silva, Joana; Pinteus, Susete; Fitas, Manuel; Pinto, Pedro; Marto, Joana; Ribeiro, HelenaThis work addresses the potential of the red seaweed Gelidium corneum as a source of bioactive ingredients for skin health and wellness in response to the growing awareness regarding the significance of sustainable strategies in developing new nature-based dermocosmetic products. Hydroalcoholic extracts from the dried biomass were subjected to sequential liquid–liquid partitions, affording five different fracti...
Lanthanide-based organic salts: Synthesis, characterization, and cytotoxicity s...
Forte, Andreia; Gago, Sandra; Alves, Celso; Silva, Joana; Pedrosa, Rui; Laia, César A.T.; Marrucho, Isabel M.; Branco, Luis C.The formulation of magnetic ionic liquids (MILs) or organic salts based on lanthanides as anions has been explored. In this work, a set of choline-family-based salts, and two other, different cation families, were combined with Gadolinium(III) and Terbium(III) anions. Synthetic methodologies were previously optimized, and all organic salts were obtained as solids with melting temperatures higher than 100 °C. Th...
Marine natural products as anticancer agents 2.0
Alves, Celso; Diederich, Marc[Introduction] Global cancer incidence and death are expected to increase to 28.4 million cases by 2040, despite efforts to understand cancer biology better and to improve its diagnosis and therapy [1]. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes [2]. Over the last few decades, the marine envi...
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Márcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1-100 µM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...
Disclosing the antitumour potential of the marine bromoditerpene sphaerococceno...
Alves, Celso; Silva, Joana; Afonso, Marta B.; Guedes, Romina A.; Guedes, Rita C.; Alvariño, Rebeca; Pinteus, Susete; Gaspar, Helena; Goettert, Marcia I.Nature has revealed to be a key source of innovative anticancer drugs. This study evaluated the antitumour potential of the marine bromoditerpene sphaerococcenol A on different cancer cellular models. Dose-response analyses (0.1–100 μM; 24 h) were accomplished in eight different tumour cell lines (A549, CACO-2, HCT-15, MCF-7, NCI-H226, PC-3, SH-SY5Y, SK-MEL-28). Deeper studies were conducted on MFC-7 cells, nam...