Alginates isolated from Sargassum vulgare , present a strong antitumor activity, associated with kidney reversible damage, as analysed by histopathology of treated animals. In the present study, the renal alteration mechanisms of S. vulgare alginates were investigated using the isolated perfused rat kidney and the isolated perfused rat mesenteric blood vessel methods. The results showed that the effects of Sarg...
The accident caused by the snake Lachesis muta muta is serious and its venom is responsible for many systemic changes, such as hypotension. In this work, the renal effects of the total venom of this snake in the renal perfusion system and in cultured renal tubular cells of the type MDCK (Madin-Darby Canine Kidney) are investigated. Isolated kidneys from Wistar rats, weighing 250 to 300g, were perfused with prev...