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Contributions of cytogenetics to cancer research

Oliveira-Junior, Robson José de; Goulart Filho, Luiz Ricardo; Bastos, Luciana Machado; Alves, Dhiego de Deus; Silva, Sabrina Vaz dos Santos e

The two conflicting visions of tumorigenesis that are widely discussed are the gene-mutation hypothesis and the aneuploidy hypothesis. In this review we will summarize the contributions of cytogenetics in the study of cancer cells and propose a hypothetical model to explain the influence of cytogenetic events in carcinogenesis, emphasizing the role of aneuploidy. The gene mutation hypothesis states that gene-sp...

Date: 2013   |   Origin: Oasisbr
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