3 documents found, page 1 of 1
Role of adenosine in epilepsy and seizures
Tescarollo, Fabio C.; Rombo, Diogo M.; DeLiberto, Lindsay K.; Fedele, Denise E.; Alharfoush, Enmar; Tomé, Ângelo R.; Cunha, Rodrigo A.; Sebastião, Ana MAdenosine is an endogenous anticonvulsant and neuroprotectant of the brain. Seizure activity produces large quantities of adenosine, and it is this seizure-induced adenosine surge that normally stops a seizure. However, within the context of epilepsy, adenosine plays a wide spectrum of different roles. It not only controls seizures (ictogenesis), but also plays a major role in processes that turn a normal brain...
From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?
Flaten, Vanessa; Laurent, Cyril; Coelho, Joana E; Sandau, Ursula; Batalha, Vânia; Burnouf, Sylvie; Hamdane, Malika; Humez, Sandrine; Boison, DetlevAD (Alzheimer's disease) is the most prevalent form of dementia in the aged population. Definitive diagnosis of AD is based on the presence of senile plaques and neurofibrillary tangles that are identified in post-mortem brain specimens. A third pathological component is inflammation. AD results from multiple genetic and environmental risk factors. Among other factors, epidemiological studies report beneficial ...
Adenosine A₂A receptors in striatal glutamatergic terminals and GABAergic neuro...
Shen, Hai-Ying; Canas, Paula M.; Garcia-Sanz, Patricia; Lan, Jing-Quan; Boison, Detlev; Moratalla, Rosario; Cunha, Rodrigo A.; Chen, Jiang-FanAdenosine A2A receptors (A2AR) are located postsynaptically in striatopallidal GABAergic neurons, antagonizing dopamine D2 receptor functions, and are also located presynaptically at corticostriatal terminals, facilitating glutamate release. To address the hypothesis that these two A2AR populations differently control the action of psychostimulants, we characterized A2AR modulation of cocaine-induced effects at...