Lung cancer (LC) is a leading cause of cancer-related mortality worldwide. Lung Cancer Screening (LCS) programs that use low-dose computed tomography (LDCT) have been shown to reduce LC mortality by up to 25 % and are considered cost-effective. The European Health Union has encouraged its Member States to explore the feasibility of LCS implementation in their respective countries. The task force conducted a com...
Over time, industries are starting to be concern about their impact on the environment, and therefore new technologies, have arrived with the capability of improving the sustainability of the industrial paradigm. Machine Learning (ML) and Artificial Intelligence (AI) are taking over the global industry, by offering new data drive solutions capable of optimizing decision-making and operation. Meanwhile, new adva...
The Aspergillus niger CexA transporter belongs to the DHA1 (Drug-H+ antiporter) family. CexA homologs are exclusively found in eukaryotic genomes, and CexA is the sole citrate exporter to have been functionally characterized in this family so far. In the present work, we expressed CexA in Saccharomyces cerevisiae, demonstrating its ability to bind isocitric acid, and import citrate at pH 5.5 with low affinity. ...
This paper examines the distinct types of modified auditor opinions and the non-compliance with the legal certification of accounts, to assess whether they provide different relevant informational content on the risk of impending bankruptcies. The study also addresses the signalling effects when firms do not comply with disclosure obligations. Controlling for the a priori risk classification, we find that disti...
Meagre (Argyrosomus regius) forms ephemeral aggregations during the reproductive season that, given the large size and high commercial value of this species, lead to increased risk of overexploitation. Data paucity together with the inability to apply classical fisheries assessment techniques and management measures due to the seasonally-elusive dynamics of adult meagre, and the diffuse nature of artisanal fish...
Na Unidade Curricular Estágio V – Enfermagem em Saúde Mental e Psiquiatria, no 3ºAno 1ºSemestre do Curso de Enfermagem 1ºCiclo, no âmbito do processo de cuidados à pessoa com doença mental surgiu a oportunidade de planear intervenções tendo por base os objetivos SMART. Um dos componentes na recuperação da pessoa é a definição de objetivos (Parsons et al., 2016). O método SMART, defende que os objetivos criados ...
Como aferir e monitorizar desigualdades sociais na sociedade portuguesa contemporânea, nomeadamente à escala regional? Os debates científicos contemporâneos apelam para que as problemáticas das desigualdades e do desenvolvimento se aproximem entre si. Este artigo pretende ser um contributo para a compreensão das relações entre estas problemáticas, considerando as desigualdades sociais do país, as suas assimetri...
Aim: Assess knowledge and attitude towards the gradual reduction of salt in bread and the potential impact on eating habits of children (6-18 years) and their families, as part as a Health Impact Assessment pilot study.
The need to overcome logistic and ethical limitations of in vivo nanotoxicity evaluation in marine organisms is essential, mostly when dealing with fish. It is well established that medium/solvent conditions affect dispersion and agglomeration of nanoparticles (NPs), which represents a constraint towards a solid and realistic toxicity appraisal. In this way the pros and cons of an ex vivo approach, using a simp...