Candida albicans, a commensal opportunistic pathogen, exhibits remarkable metabolic flexibility and adaptability to environmental changes. In glucose-limited niches, it utilizes alternative carbon sources such as carboxylic acids, which may influence its pathogenicity. In Saccharomyces cerevisiae, the uptake of monocarboxylates occurs through regulated plasma membrane (PM) transport proteins, such as Ato1 (Ady2...
The present work presents a new approach to studying the structural integrity of a Ti-6Al-4V alloy obtained by Selective Laser Melting (SLM). This approach is based on the intrinsic addictive manufacturing defects analysis obtained by nanotomography, the experimental S-N curve, and the small crack growth Murakami and Endo model. Also, two counting methods of 3D manufacturing intrinsic defects were considered. T...
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Esta dissertação investiga a integração da Inteligência Artificial (IA) na Gestão de Projetos (GP), para otimizar os resultados gerais de projetos. Ao analisar a literatura atual sobre tecnologias de IA e práticas tradicionais e Agile de gestão de projetos, o estudo explora como ferramentas tal como “machine learning”, análise preditiva e automação podem melhorar a tomada de decisões, a distribuição de recursos...
Introduction and objectives: Left ventricular global longitudinal strain (LVGLS) is an indicator of myocardial function in patients with heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). Nevertheless, it is not clear whether LVGLS correlates with filling pressures and cardiac output (CO) in an ambulatory setting. We aimed to assess whether LVGLS is associated with inv...
Objective: Malignant melanoma (MM) is among the most lethal skin cancers, with early diagnosis being essential for timely treatment and favorable prognosis. The coronavirus disease 19 (COVID-19) pandemic-related disruptions in global healthcare systems affected cancer screening and treatment. The aim of this study was to investigate the potential impact of the COVID-19 pandemic on the diagnosis and prognosis of...
Introduction and objectives: Left ventricular global longitudinal strain (LVGLS) is an indicator of myocardial function in patients with heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF). Nevertheless, it is not clear whether LVGLS correlates with filling pressures and cardiac output (CO) in an ambulatory setting. We aimed to assess whether LVGLS is associated with inv...
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Imagine a conversation between Filippo Tommaso Marinetti, Walter Benjamin, and Gilbert Simondon, set against the backdrop of mid-20th century modern warfare. Using the cut-up technique, excerpts retrieved from Simondon's On Techno-Aesthetics and Benjamin's The Work of Art in the Age of Technical Reproduction and To the Planetarium are assembled into a dialogue. Marinetti passionately extols the virtues of speed...