12 documents found, page 1 of 2
Hyperoside Supplementation in Preservation Media Surpasses Vitamin C Protection...
Moreira, Mafalda V; Pereira, Sara C; Guerra-Carvalho, Bárbara; Carrageta, David F; Pinto, Soraia; Barros, Alberto; Silva, Branca M.; Oliveira, Pedro F.Oxidative Stress (OS) is reported as one of the main causes of male infertility. Infertile couples often resort to assisted reproductive technology (ART) to achieve parenthood. However, preparation for ART protocols increases the exposer of gametes to OS. Thus, it is crucial to find suitable preservation media that can counteract the OS-induced damages in spermatozoa. In this work, we tested and compared the ef...
Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenerge...
Correia, Sónia C.; Machado, Nuno J.; Alves, Marco G; Oliveira, Pedro F.; Moreira, Paula I.The lack of effective disease-modifying therapeutics to tackle Alzheimer's disease (AD) is unsettling considering the actual prevalence of this devastating neurodegenerative disorder worldwide. Intermittent hypoxic conditioning (IHC) is a powerful non-pharmacological procedure known to enhance brain resilience. In this context, the aim of the present study was to investigate the potential long-term protective i...
Inheritable testicular metabolic memory of high-fat diet causes transgeneration...
Crisóstomo, Luís; Jarak, Ivana; Rato, Luís P; Raposo, João F; Batterham, Rachel L; Oliveira, Pedro F.; Alves, Marco GThe consumption of energy-dense diets has contributed to an increase in the prevalence of obesity and its comorbidities worldwide. The adoption of unhealthy feeding habits often occurs at early age, prompting the early onset of metabolic disease with unknown consequences for reproductive function later in life. Recently, evidence has emerged regarding the intergenerational and transgenerational effects of high-...
The Action of Polyphenols in Diabetes Mellitus and Alzheimer's Disease: A Commo...
Silveira, Ana C.; Dias, Jane; Santos, Vanessa M.; Oliveira, P.F.; Alves, Marco G; Rato, Luís; Silva, Branca M.Diabetes Mellitus (DM) and Alzheimer's disease (AD) are two prevalent diseases in modern societies, which are caused mainly by current lifestyle, aging and genetic alterations. It has already been demonstrated that these two diseases are associated, since individuals suffering from DM are prone to develop AD. Conversely, it is also known that individuals with AD are more susceptible to DM, namely type 2 diabete...
L-Theanine promotes cultured human Sertoli cells proliferation and modulates gl...
Dias, T. R.; Bernardino, Raquel; Alves, Marco G; Silva, Joaquina; Barros, Alberto; Sousa, Mário; Casal, Susana; Silva, Branca M.; Oliveira, P.F.L-Theanine is the major free amino acid present in tea (Camellia sinensis L.). The effects of several tea constituents on male reproduction have been investigated, but L-theanine has been overlooked. Sertoli cells (SCs) are essential for the physical and nutritional support of germ cells. In this study, we aimed to investigate the ability of L-theanine to modulate important mechanisms of human SCs (hSCs) metabo...
8-(3-phenylpropyl)-1,3,7-triethylxanthine is a synthetic caffeine substitute wi...
Carrageta, David F; Dias, Tânia R.; Jarak, Ivana; Alves, Marco G; Oliveira, P.F.; Walt, Mietha Van Der; Terre'Blanche, Gisella; Monteiro, Mariana P.Caffeine is one of the most worldwide consumed methylxanthines. It is well-known for its thermogenic and cell metabolism modulating effects. Based on methylxanthines' chemical structure, 8-(3-phenylpropyl)-1,3,7-triethylxanthine (PTX) is a novel adenosine antagonist with higher receptor affinity than caffeine. Therefore, we hypothesized that PTX metabolic effects could be stronger than those of caffeine. For th...
Pharmacological potential of methylxanthines: Retrospective analysis and future...
Monteiro, João; Alves, Marco G; Oliveira, P.F.; Silva, Branca M.Methylated xanthines (methylxanthines) are available from a significant number of different botanical species. They are ordinarily included in daily diet, in many extremely common beverages and foods. Caffeine, theophylline and theobromine are the main methylxanthines available from natural sources. The supposedly relatively low toxicity of methylxanthines, combined with the many beneficial effects that have be...
Bioactive Substances from Medicinal Plants for Metabolic Disorders
Silva, Branca M.; Oliveira, Pedro F.; Alves, Marco G; Dias, Tânia R.Metabolic disorders, particularly Diabetes Mellitus (DM), are major causes of death worldwide. In fact, the world statistics for DM are alarming: this epidemic disease kills one person every six seconds, being the fourth cause of death. Besides the health issues, the costs associated with DM, and its co-morbidities, are massive and the pressure in National Health Care Systems is dramatically increasing. Patient...
Obesity, energy balance and spermatogenesis
Oliveira, Pedro F.; Sousa, Mário; Silva, Branca M.; Monteiro, Mariana P; Alves, Marco GObesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent comorbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reprod...
Implications of epigallocatechin-3-gallate in cultured human Sertoli cells glyc...
Dias, Tânia R.; Alves, Marco G; Silva, Joaquina; Barros, Alberto; Sousa, Mário; Casal, Susana; Silva, Branca M.; Oliveira, Pedro F.Sertoli cells are crucial for the success of spermatogenesis, which is the biological process that ensures male fertility. These cells present high metabolic rates, being often subjected to high oxidative stress levels that, if uncontrolled, may compromise male fertility. Since the most abundant tea catechin, epigallocatechin-3-gallate (EGCG), has demonstrated a potent preventive activity against oxidative stre...