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Energetics of Male Reproduction
Bastos, Ana; Alves, Marco G.; Silva, Branca M.; Oliveira, Pedro F.; Rato, LuísSpermatogenesis is a finely tuned process marked by specific metabolic adjustments at each stage of germ cell differentiation and sperm production. The Sertoli cell, often referred to as the "nurse cell," assumes a pivotal role in furnishing germ cells with the requisite metabolic substrates for their sustenance and differentiation. This dynamic establishes a continual metabolic partnership between Sertoli cell...
Counteracting Colon Cancer by Inhibiting Mitochondrial Respiration and Glycolys...
Bessa, Cláudia; Loureiro, Joana B.; Barros, Matilde; Isca, Vera M. S.; Sardão, Vilma A.; Oliveira, Paulo J.; Bernardino, Raquel L.Metabolic reprogramming is a central hub in tumor development and progression. Therefore, several efforts have been developed to find improved therapeutic approaches targeting cancer cell metabolism. Recently, we identified the 7a-acetoxy-6b-benzoyloxy-12-O-benzoylroyleanone (Roy- Bz) as a PKC -selective activator with potent anti-proliferative activity in colon cancer by stimulating a PKC -dependent mitochondr...
The influence of adipocyte secretome on selected metabolic fingerprints of brea...
Luís, Carla; Guerra-Carvalho, Bárbara; Braga, Patrícia C.; Guedes, Carla; Patrício, Emília; Alves, Marco G.; Fernandes, Ruben; Soares, RaquelMolecular subtype (MS) is one of the most used classifications of breast cancer (BC). Four MSs are widely accepted according to receptor expression of estrogen, progesterone, and HER2. The impact of adipose tissue on BC MS metabolic impairment is still unclear. The present work aims to elucidate the metabolic alterations in breast cancer cell lines representing different MSs subjected to adipocyte associated fa...
Exenatide and Dapagliflozin Combination Enhances Sertoli Cell Secretion of Key ...
Ribeiro, João C.; Martins, Ana D.; Jarak, Ivana; Carvalho, Rui A.; Alves, Marco G.; Oliveira, Pedro F.The incidence of metabolic diseases such as type 2 diabetes mellitus (DM) and obesity has been increasing dramatically. Both diseases are closely linked and new approaches for type 2 DM treatment aim to enable weight loss. A combined therapy of dapagliflozin and exenatide has been used against type 2 DM, influencing allbody glucose dynamics. Spermatogenesis is highly dependent on the metabolic cooperation estab...
The impact of metabolic syndrome and type 2 diabetes Mellitus on prostate cancer
Sousa, André P.; Costa, Raquel; Alves, Marco G.; Soares, Raquel; Baylina, Pilar; Fernandes, RúbenProstate cancer (PCa) remains the second most common type of cancer in men worldwide in 2020. Despite its low death rate, the need for new therapies or prevention strategies is critical. The prostate carcinogenesis process is complex and multifactorial. PCa is caused by a variety of mutations and carcinogenic events that constitutes the disease’s multifactorial focus, capable of not only remodeling cellular act...
Effects of Age and Lifelong Moderate-Intensity Exercise Training on Rats' Testi...
Silva, Joana V.; Santiago, Joana; Matos, Bárbara; Henriques, Magda C.; Patrício, Daniela; Martins, Ana D.; Duarte, José A.; Ferreira, RitaAging is associated with testicular morphological and functional alterations, but the underlying molecular mechanisms and the impact of physical exercise are poorly understood. In this study, we examined the effects of age and lifelong moderate-intensity exercise on rat testis. Mature adults (35 weeks) and middle-aged (61 weeks) Wistar Unilever male rats were maintained as sedentary or subjected to a lifelong m...
Metabolomic Profiling in Lung Cancer: A Systematic Review
Madama, Daniela; Martins, Rosana; Pires, Ana S.; Botelho, Maria F.; Alves, Marco G.; Abrantes, Ana M.; Cordeiro, Carlos R.Lung cancer continues to be a significant burden worldwide and remains the leading cause of cancer-associated mortality. Two considerable challenges posed by this disease are the diagnosis of 61% of patients in advanced stages and the reduced five-year survival rate of around 4%. Noninvasively collected samples are gaining significant interest as new areas of knowledge are being sought and opened up. Metabolomi...
Plasmatic Oxidative and Metabonomic Profile of Patients with Different Degrees ...
Silva-Vaz, Pedro; Jarak, Ivana; Rato, Luis; Oliveira, Pedro F.; Morgado-Nunes, Sara; Paulino, Aida; Castelo-Branco, Miguel; Botelho, FilomenaAcute pancreatitis (AP) is an inflammatory process of the pancreas with variable involvement of the pancreatic and peripancreatic tissues and remote organ systems. The main goal of this study was to evaluate the inflammatory biomarkers, oxidative stress (OS), and plasma metabolome of patients with different degrees of biliary AP severity to improve its prognosis. Twenty-nine patients with biliary AP and 11 heal...
Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Disse...
Loureiro, Joana B.; Raimundo, Liliana; Calheiros, Juliana; Carvalho, Carla; Barcherini, Valentina; Lima, Nuno R.; Gomes, Célia; Almeida, Maria InêsMelanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two- and...
Targeting p53 for melanoma treatment: counteracting tumour proliferation, disse...
Loureiro, Joana B.; Raimundo, Liliana; Calheiros, Juliana; Carvalho, Carla; Barcherini, Valentina; Lima, Nuno R.; Gomes, Célia; Almeida, Maria InêsMelanoma is the deadliest form of skin cancer, primarily due to its high metastatic propensity and therapeutic resistance in advanced stages. The frequent inactivation of the p53 tumour suppressor protein in melanomagenesis may predict promising outcomes for p53 activators in melanoma therapy. Herein, we aimed to investigate the antitumor potential of the p53-activating agent SLMP53-2 against melanoma. Two- and...