5 documents found, page 1 of 1
Identificação de alterações moleculares associadas à expressão de CD133, CXCR4,...
Alves, Markênia Kélia SantosALVES, Markênia Kélia Santos. Identificação de alterações moleculares associadas à expressão de CD133, CXCR4, CD44 E OLIG2 e metilação em promotor de CDKN2A em tumores astrocíticos. 2014. 89 f. Tese (Doutorado em biotecnologia)- Universidade Federal do Ceará, Fortaleza-CE, 2014.; Currently, the concept that tumors are cell populations organized in a hierarchically heterogenous way in which stem-cells are releva...
Differential expression of MYC in H. pylori-related intestinal
Fernandes, Isabelle Joyce de Lima Silva; Alves, Markênia Kélia Santos; Lima, Valeska Portela; Lima, Marcos Antônio Pereira deEvidence suggests that the carcinogenic process guided by Helicobacter pylori is related to the expression of cell cycle and apoptosis proteins as BCL-2, BAX, and MYC. However, the literature is conflicting regarding the expression frequency in the histological subtypes and did not consider cagA gene presence. To investigate the expression of these proteins considering the histological subtypes of gastric cance...
Prevalence of Helicobacter pylori genotypes (vacA, cagA, cagE and virB11) in ga...
Lima, Valeska Portela; Silva-Fernandes, Isabelle Joyce de Lima; Alves, Markênia Kélia Santos; Rabenhorst, Silvia Helena BaremPurpose: To investigate the frequency and the association of vac A alleles, cag A, cag E and vir B11 genes of Helicobacter pylori from patients with gastric cancer, considering the clinic histopathological parameters. Methods : One hundred and one gastric adenocarcinoma tissues were assessed by PCR to detect H. pylori and vac A alleles, cag A, cag E and vir B11. Results : The distribution of cases according to ...
p27 KIP1 expression in gastric cancer : differential pathways in the histologic...
Alves, Markênia Kélia Santos; Lima, Valeska Portela; André, Ângela Rosa; Ferreira, Márcia Valéria Pitombeira; Barros, Marcos Aurélio PessoaObjective. Decreases in p27 KIP1 and C-MYC expression have been associated with Helicobacter pylori infection. Furthermore, C-MYC seems to be a transcriptional repressor of p27 KIP1 . Therefore, in a series of gastric adenocarcinomas we studied the association of p27 KIP1 expression with H. pylori genotype ( vac A, cag A, cag E and vir B11) and the involvement of C-MYC in this process. Material and methods. Exp...
MTHFR C677T polymorphism and differential methylation status in gastric cancer ...
Neves Filho, Eduardo Henrique Cunha; Alves, Markênia Kélia Santos; Lima, Valeska Portela; Rabenhorst, Silvia Helena BaremAbstract MTHFR C677T and Helicobacter pylori infec- tion are believed to play critical roles in the DNA methylation process, an epigenetic feature frequently found in gastric cancer. The aim of this study was to verify the associations between the MTHFR C677T polymorphism and the methylation status of three gastric cancer-related genes. The influence of H. pylori strains was also assessed. DNA extracted from 71...