22 documents found, page 1 of 3
Added value of lymphocyte subpopulations in the classification of Sjögren's syn...
Barcelos, F; Brás-Geraldes, C; Martins, C; Papoila, AL; Monteiro, R; Cardigos, J; Madeira, N; Alves, N; Vaz-Patto, J; Cunha-Branco, J; Borrego, LMSjögren's Syndrome (SjS) is a chronic systemic immune-mediated inflammatory disease characterized by lymphocytic infiltration and consequent lesion of exocrine glands. SjS diagnosis and classification remains a challenge, especially at SjS onset, when patients may have milder phenotypes of the disease or uncommon presentations. New biomarkers are needed for the classification of SjS, thus, we aimed to evaluate ...
Added Value of Lymphocyte Subpopulations in the Classification of Sjögren's Syn...
Barcelos, F; Brás-Geraldes, C; Martins, C; Papoila, AL; Monteiro, R; Cardigos, J; Madeira, N; Alves, N; Vaz-Patto, J; Cunha-Branco, J; Borrego, LMSjögren's Syndrome (SjS) is a chronic systemic immune-mediated inflammatory disease characterized by lymphocytic infiltration and consequent lesion of exocrine glands. SjS diagnosis and classification remains a challenge, especially at SjS onset, when patients may have milder phenotypes of the disease or uncommon presentations. New biomarkers are needed for the classification of SjS, thus, we aimed to evaluate ...
Corneal Sub‐Basal Nerve Plexus Assessment and its Association with Phenotypic F...
Barcelos, F; Hipólito‐Fernandes, D; Martins, C; Ângelo‐Dias, M; Cardigos, J; Monteiro, R; Alves, N; Vaz‐Patto, J; da Cunha‐Branco, J; Borrego, LMlPurpose: To assess and compare corneal sub-basal nerve plexus morphology with circulating lymphocyte subsets, immunologic status and disease activity in Sjögren syndrome (SjS) patients. Methods: Fifty-five SjS patients, 63 Sicca patients (not fulfilling SjS criteria), 18 rheumatoid arthritis (RA) patients and 20 healthy controls (HC) were included. Systemic disease activity in SjS was assessed with the ESSDAI s...
Association between EBV serological patterns and lymphocytic profile of SjS pat...
Barcelos, F; Martins, C; Monteiro, R; Cardigos, J; Prussiani, T; Sítima, M; Alves, N; Vaz-Patto, JA; Cunha-Branco, J; Borrego, LMSjögren's syndrome (SjS) is characterized by lymphocytic infiltration of exocrine glands, i.e. autoimmune epithelitis. Lymphocytes are central in SjS pathogenesis, with B-cell hyperactivity mediated by T-cells. B-cells are main targets of Epstein-Barr virus (EBV) infection, a frequently-suggested trigger for SjS. We aimed to evaluate how the EBV infection modulates B and T-cell subsets in SjS, including as cont...
Intraocular Lens Power Calculation Formulas Accuracy in Combined Phacovitrectom...
Hipólito-Fernandes, D; Luís, ME; Maleita, D; Gil, P; Maduro, V; Costa, L; Marques, N; Branco, J; Alves, NBackground: Our study aimed to assess and compare the accuracy of 8 intraocular lens (IOL) power calculation formulas (Barrett Universal II, EVO 2.0, Haigis, Hoffer Q, Holladay 1, Kane and PEARL-DGS) in patients submitted to combined phacovitrectomy for vitreomacular (VM) interface disorders. Methods: Retrospective chart review study including axial-length matched patients submitted to phacoemulsification alone...
Lymphocyte Subpopulations in Sjögren’s Syndrome Are Distinct in Anti-SSA-Positi...
Barcelos, F; Martins, C; Madeira, N; Dias, M; Cardigos, J; Alves, N; Vaz-Patto, J; Cunha-Branco, J; Borrego, LMObjectives: Sjögren's syndrome (SjS) patients exhibit great phenotypical heterogeneity, reinforced by the positiveness of anti-SSA antibody. We aimed to evaluate lymphocyte subpopulations in SSA-positive (SSA+SjS) and SSA-negative (SSA-SjS) SjS patients, Sicca patients, and healthy controls (HC), and to investigate associations between lymphocyte subpopulations and disease activity in SjS. Methods: According to...
VRF-G, a New Intraocular Lens Power Calculation Formula: A 13-Formulas Comparis...
Hipólito-Fernandes, D; Luís, ME; Gil, P; Maduro, V; Feijão, J; Yeo, T; Voytsekhivskyy, O; Alves, NPurpose: To compare the accuracy of a newly developed intraocular lens (IOL) power formula (VRF-G) with twelve existing formulas (Barret Universal II, EVO 2.0, Haigis, Hill-RBF 2.0, Hoffer Q, Holladay 1, Kane, Næeser 2, PEARL-DGS, SRK/T, T2 and VRF). Methods: Retrospective case series including 828 patients having uncomplicated cataract surgery with the implantation of a single IOL model (SN60WF). Using optimis...
Abordagem clínica da cirrose hepática: protocolos de atuação
Reis, J; Alves, N; Martins, A; Horta, D; Alberto, S; Santos, L; Carvalho, R; Rodrigues, C; Oliveira, A; Costa, M; Lourenço, L; Branco, J; Cardoso, M
Association Between Memory B-Cells and Clinical and Immunological Features of P...
Barcelos, F; Martins, C; Papoila, A; Geraldes, C; Cardigos, J; Nunes, G; Lopes, T; Alves, N; Vaz-Patto, J; Branco, J; Borrego, LMB-cells play a pivotal role in primary Sjögren's syndrome (pSS) pathogenesis. We aim to (1) evaluate the distribution of B-lymphocyte subpopulations in pSS and Sicca patients, (2) establish cut-off points that discriminate pSS from controls, (3) evaluate the association between memory B-cells and phenotypic features in pSS. We included 57 pSS patients, 68 Sicca and 24 healthy controls. Circulating B-cells were ...
Análise das Camadas Retinianas em Doentes com Lesão Isquémica da Artéria Cerebr...
Anjos, R; Cardigos, J; Costa, L; Borges, B; Alves, N; Amado, D; Ferreira, J; Cunha, JPIntrodução: A degeneração transneuronal retrógrada (DTR) das células ganglionares tem sido implicada na fisiopatologia de lesões na via visual posterior. Apesar de estarem descritas alterações nas camadas mais externas da retina na patologia do nervo óptico, esta relação com lesões a nível occipital permanece desconhecida. O objectivo do presente estudo é a avaliação das camadas nuclear interna (CNi), plexiform...