2 documents found, page 1 of 1
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astroglio...
Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Patrício, Patrícia; Araújo, Bruna Alexandra Vale; Alves, Nuno Dinis; Mateus-Pinheiro, AntónioDepression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, l...