3 documents found, page 1 of 1
Synthesis and structure-activity relationships of new chiral spiro-β-lactams hi...
Alves, Nuno Guerreiro; Bártolo, Inês; Alves, Américo J. S.; Fontinha, Diana; Francisco, Denise; Lopes, Susana M. M.; Soares, Maria I. L.The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penicillanates with dual activity against HIV and Plasmodium. The spiro-β-lactams synthesized were assayed for their in vitro activity against HIV-1, providing relevant structure-activity relationship information. Among the te...
Recent Advances in the Synthesis of Spiro‐β‐Lactams and Spiro‐δ‐Lactams
Alves, Nuno Guerreiro; Alves, Américo J. S.; Soares, Maria I. L.; Pinho e Melo, Teresa M. V. D.Spirocyclic molecules are widely recognized for their complex three-dimensional features and structural rigidity. Among this class of molecules, the spiro-lactams subclass stands out, being extensively explored due to its bioactivity and utility in a variety of scientific fields such as drug design and organic synthesis. Given the recognition of spirocyclic lactams’ broad potential, several efforts have been en...
Synthesis and structure-activity relationships of new chiral spiro-β-lactams hi...
Alves, Nuno Guerreiro; Bártolo, Inês; Alves, Américo J.S.; Fontinha, Diana; Francisco, Denise; Lopes, Susana M.M.; Soares, Maria I.L.The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penicillanates with dual activity against HIV and Plasmodium. The spiro-β-lactams synthesized were assayed for their in vitro activity against HIV-1, providing relevant structure-activity relationship information. Among the te...