4 documents found, page 1 of 1
The influence of feeder cell-derived extracellular matrix density on thymic epi...
Silva, Catarina S.; Pinto, Rute D.; Pires, R. A.; Correia-Neves, M; Reis, R. L.; Alves, Nuno L.; Martins, Albino; Neves, N. M.The thymus is responsible for the selection and development of T cells, having an essential role in the establishment of adaptive immunity. Thymic epithelial cells (TECs) are key players in T cell development interacting with thymocytes in the thymic 3D environment. Feeder-layer cells have been frequently used as platforms for the successful establishment of TEC cultures. Nevertheless, the role of the feeder ce...
The Portuguese Society for Immunology - SPI: history and mission
Alves, Nuno L.; Carvalho, Agostinho; Serre, Karine; Martins, Vera C.; Saraiva, MargaridaThe SPI (Figure 1) was founded in 1973 by group of 13 immunologists who felt the need to create a platform dedicated to education, interaction and state of the art discussion in fundamental and clinical immunology in Portugal. Since then, the Portuguese scientific landscape has tremendously expanded in size, quality and international competitiveness, with the SPI and its members following the same trend. Curren...
Innate IFN-γ-Producing Cells Developing in the Absence of IL-2 Receptor Common ...
Resende, Mariana; Cardoso, Marcos S.; Ribeiro, Ana R.; Flórido, Manuela; Borges, Margarida; Castro, António G.; Alves, Nuno L.; Cooper, Andrea M.IFN-gamma is known to be predominantly produced by lymphoid cells such as certain subsets of T cells, NK cells, and other group 1 innate lymphoid cells. In this study, we used IFN-gamma reporter mouse models to search for additional cells capable of secreting this cytokine. We identified a novel and rare population of nonconventional IFN-gamma-producing cells of hematopoietic origin that were characterized by t...
Lymphotoxin-β receptor in microenvironmental cells promotes the development of ...
Fernandes, Mónica T.; Ghezzo, Marinella N.; Silveira, André B.; Kalathur, Ravi K.; Póvoa, Vanda; Ribeiro, Ana R.; Brandalise, Sílvia R.Lymphotoxin-mediated activation of the lymphotoxin-β receptor (LTβR; LTBR) has been implicated in cancer, but its role in T-cell acute lymphoblastic leukaemia (T-ALL) has remained elusive. Here we show that the genes encoding lymphotoxin (LT)-α and LTβ (LTA, LTB) are expressed in T-ALL patient samples, mostly of the TAL/LMO molecular subtype, and in the TEL-JAK2 transgenic mouse model of cortical/mature T-ALL (...