7 documents found, page 1 of 1
Cerebral venous thrombosis following an immunoglobulin-E mediated anaphylactic ...
Dias Da Costa, Mariana; Alves, Pedro Nascimento; de Sousa, Diana Aguiar; Canhão, PatríciaBackground: Prothrombotic and pro-inflammatory states are known cerebral venous thrombosis risk factors. To date, two cases of venous thrombotic events after immunoglobulin-E mediated anaphylaxis have been reported. Herein, we describe the first case of cerebral venous thrombosis in close temporal relation with an immunoglobulin-E mediated anaphylactic event. Case description: A 51-year-old female presented wit...
Delusions of space after stroke : clinical phenomenology and neural basis
Alves, Pedro NascimentoOrientation in space is an important determinant of human behaviour. Spatial delusions are a disrupting form of spatial disorientation characterized by a firm conviction of place mislocation. Patients believe they are in a reduplicated, transformed or dislocated place and are rather insensitive to surrounding incongruences. Spatial delusions are frequent after right hemispheric lesions and in neurodegenerative ...
Clinical presentation and neural correlates of stroke‐associated spatial delusions
Alves, Pedro Nascimento; Fonseca, Ana Catarina; Melo, Teresa Pinho e; Martins, Isabel PavãoBackground and purpose: Incongruent beliefs about self-localization in space markedly disturb patients' behavior. Spatial delusions, or reduplicative paramnesias, are characterized by a firm conviction of place reduplication, transformation, or mislocation. Evidence suggests they are frequent after right hemisphere lesions, but comprehensive information about their clinical features is lacking. Methods: We pros...
Unravelling the neural basis of spatial delusions after stroke
Alves, Pedro Nascimento; Fonseca, Ana Catarina; Silva, Daniela; Andrade, Matilde R; Melo, Teresa Pinho e; Thiebaut de Schotten, MichelObjective: Knowing explicitly where we are is an interpretation of our spatial representations. Reduplicative paramnesia is a disrupting syndrome in which patients present a firm belief of spatial mislocation. Here, we studied the largest sample of patients with delusional misidentifications of space (i.e. reduplicative paramnesia) after stroke to shed light on their neurobiology. Methods: In a prospective, cum...
Phrenic nerve stimulation is more sensitive than ultrasound measurement of diap...
Pinto, Susana; Alves, Pedro Nascimento; Swash, Michael; Carvalho, MamedeAims of the study: To compare the assessment of respiratory decline with conventional tests, measurement of diaphragm compound muscle action potential (CMAP) to phrenic nerve stimulation and diaphragm thickness to ultrasound (US) investigation in amyotrophic lateral sclerosis (ALS) patients followed for a short period of time. Patients and methods: We evaluated in 40 consecutive ALS patients, the clinical funct...
Ultrasound for assessment of diaphragm in ALS
Pinto, Susana; Alves, Pedro Nascimento; Pimentel, Bernardo; Swash, Michael; Carvalho, MamedeObjective: To evaluate the correlation between diaphragm thickness assessed by ultrasound (US) with respiratory function tests and the diaphragm motor responses, in patients with amyotrophic lateral sclerosis (ALS). Methods: 42 consecutive ALS patients were studied (11 with bulbar-onset), excluding patients with marked orofacial paresis. Investigation included: revised ALS functional rating scale (ALSFRS-R), fo...
Overexpression of Adenosine A2A receptors in rats: effects on depression, locom...
Coelho, Joana E; Alves, Pedro Nascimento; Canas, Paula M.; Valadas, Jorge S.; Shmidt, Tatiana; Batalha, Vânia; Ferreira, Diana G.; Ribeiro, Joaquim A.Adenosine A2A receptors (A2AR) are a sub-type of receptors enriched in basal ganglia, activated by the neuromodulator adenosine, which interact with dopamine D2 receptors. Although this reciprocal antagonistic interaction is well-established in motor function, the outcome in dopamine-related behaviors remains uncertain, in particular in depression and anxiety. We have demonstrated an upsurge of A2AR associated ...