13 documents found, page 1 of 2

Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...

Paracoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...

Fungal extracellular vesicles are involved in intraspecies intracellular commun...

Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.; Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Departamento de Bioquímica e Imunologia. Ribeirão Preto, SP, Brasil.; ...

Faster cryptococcus melanization increases virulence in experimental and human ...

Cryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neofo...

Pyomelanin Synthesis in Alternaria alternata Inhibits DHN-Melanin Synthesis and...

The genus Alternaria includes several of fungi that are darkly pigmented by DHN-melanin. These are pathogenic to plants but are also associated with human respiratory allergic diseases and with serious infections in immunocompromised individuals. The present work focuses on the alterations of the composition and structure of the hyphal cell wall of Alternaria alternata occuring under the catabolism of L-tyrosin...

Laccase affects the rate of Cryptococcus neoformans nonlytic exocytosis from ma...

Nonlytic exocytosis is a process in which previously ingested microbes are expelled from host phagocytes with the concomitant survival of both cell types. This process has been observed in the interaction of Cryptococcus spp. and other fungal cells with phagocytes as distant as mammalian, bird, and fish macrophages and ameboid predators. Despite a great amount of research dedicated to unraveling this process, t...

Paracoccidioides HSP90 can be found in the cell surface and is a target for ant...

Paracoccidioidomycosis (PCM) is one of the most frequent systemic mycoses in Latin America. It affects mainly male rural workers in impoverished regions, and the therapy can last up to two years or use drugs that are very toxic. Given the need for novel safe and effective approaches to treat PCM, we have been developing monoclonal antibodies (mAbs) that could be used not only to block specific fungal targets, b...

Pyomelanin synthesis in alternaria alternata inhibits DHN-Melanin synthesis and...

The genus Alternaria includes several of fungi that are darkly pigmented by DHNmelanin. These are pathogenic to plants but are also associated with human respiratory allergic diseases and with serious infections in immunocompromised individuals. The present work focuses on the alterations of the composition and structure of the hyphal cell wall of Alternaria alternata occuring under the catabolism of L-tyrosine...

A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp

Made available in DSpace on 2020-12-12T01:42:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete their life cycle. Despite this, they developed sop...

Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal ...

Capsules from pathogenic and non-pathogenic cryptococcus spp. manifest signific...

Submitted by Lívia Oliveira (livia.oliveira2@hotmail.com) on 2012-06-28T16:23:37Z No. of bitstreams: 1 Garcia_2012.pdf: 1572444 bytes, checksum: 70c7fd3535d64524869d8286f0d2f82d (MD5); Approved for entry into archive by Regina Mello(mrmello@inmetro.gov.br) on 2012-06-28T16:30:08Z (GMT) No. of bitstreams: 1 Garcia_2012.pdf: 1572444 bytes, checksum: 70c7fd3535d64524869d8286f0d2f82d (MD5); Made available in DSpace...