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Hypotensive Effects of the Crotalus durissus cascavella Venom: Involvement of NO

Evangelista, Janaina S. A. M; Evangelista, João J. F.; Evangelista, Inez L; Nojosa, Diva M. B; Nascimento, Nilberto Robson Falcão do

Crotalus durissus cascavella is a snake native of northeastern Brazil. The aim of the study was to investigate the effects of C. d. cascavella venom on rat mean arterial pressure and vascular reactivity in the mesenteric vascular bed. The venom evoked a dose-dependent decrease in mean arterial pressure, cardiac and respiratory frequency with increased plasma nitrite levels. L-NAME (10 mg/kg) blunted both the hy...

Date: 2021 | Origin: Oasisbr

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