8 documents found, page 1 of 1
Synthesis of novel papulacandin D analogs and evaluation of their antifungal po...
Bretas, Ana Carolina Oliveira; Souza, Thiago Belarmino de; Borelli, Beatriz; Johan, Suzana; Alves, Ricardo JoséSystemic fungal infections are a growing problem in contemporary medicine and few drugs are licensed for therapy of invasive fungal infections. Differences between fungi and humans, like the presence of a cell wall in fungal cells, can be explored for designing new drugs. (1,3)-β-D-glucan synthase, an enzyme that catalyzes the synthesis of (1,3)-β-D-glucan, a structural and essential component of the fungal cel...
In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into...
Mendonça, Débora Vasconcelos Costa; Tavares, Grasiele de Sousa Vieira; Lage, Daniela Pagliara; Soyer, Tauane Gonçalves; Carvalho, Lívia MendesNew therapeutic strategies against leishmaniasis are desirable, since the treatment against disease presents problems, such as the toxicity, high cost and/or parasite resistance. As consequence, new antileishmanial compounds are necessary to be identified, as presenting high activity against Leishmania parasites, but low toxicity in mammalian hosts. Flau-A is a naphthoquinone derivative recently showed to prese...
Para além da oração : uma descrição sistêmico-funcional do sistema de conjunção...
Alves, Ricardo JoséPrograma de Pós-Graduação em Letras. Departamento de Letras, Instituto de Ciências Humanas e Sociais, Universidade Federal de Ouro Preto.; Nos estudos das gramáticas tradicional (cf. CUNHA; CINTRA, 1983; KURY, 1991; LIMA, 1999) e descritiva (cf. PERINI, 1995; AZEREDO, 1999; BECHARA, 2009), as conjunções são analisadas no nível da oração, em frases isoladas, muitas vezes criadas pelos próprios autores. Devido a ...
Synthesis and evaluation of platinum complexes with potential antitumor activity
Freire, Rachel Lima Marcelino; Marques, Maria Betânia de Freitas; Souza-Fagundes, Elaine Maria de; Oliveira, Renata Barbosa de; Alves, Ricardo JoséA novel series of platinum (II) complexes was synthesized and the complexes were evaluated for their in vitro cytotoxicity against four human cancer cells lines. Five platinum complexes showed activity against at least one tumor cell line. Complexes 3 and 6 were promising, being active, at micromolar concentrations, against all the assayed tumor cell lines. Compound 3 was selected for further studies in mice wi...
Synthesis, antileishmanial activity and QSAR studies of 2-chloro- N -arylacetam...
Lavorato, Stefânia Neiva; Duarte, Mariana Costa; Andrade, Pedro Henrique Rocha De; Coelho, Eduardo Antonio Ferraz; Alves, Ricardo JoséWe describe herein the synthesis and evaluation of the antileishmanial activity against promastigote forms of Leishmania amazonensis and cytotoxicity to murine macrophages of a series of 2-chloro-N-arylacetamide derivatives. All compounds were active, except one (compound 3). Compound 5 presented the most promising results, showing good antileishmanial activity (CI50=5.39±0.67 µM) and moderate selectivity (SI=6...
Treatment of murine visceral leishmaniasis using an 8-hydroxyquinoline-containi...
Duarte, Mariana Costa; Lage, Letícia Martins dos Reis; Lage, Daniela Pagliara; Martins, Vivian Tamietti; Carvalho, Ana Maria Ravena SeverinoNewtherapeutics are urgently needed to treat visceral leishmaniasis (VL). Due to the fact that drug discovery is a long and expensive process, the development of delivery systems to carry old and toxic drugs could be considered, as well as the evaluation of new molecules that have already shown to present biological activity. In this context, the present study evaluated the in vitro and in vivo antileishmanial ...
Síntese de amidas e sulfonamidas de d-galactopiranosilamina e lactosilamina e a...
Butera, Anna Paola; Souza Filho, José Dias de; Carvalho, Diogo Teixeira; Figueiredo, Rute Cunha; Faria, Luiz Carlos Alves deWe report herein the synthesis of some -D-galactopyranosylamine and -lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in a hemagglutination inhibitory activity assay. D-Galactose and lactose were used as reference compounds. The -lactosylamine amides and sulfonamides were nearly a...
Participation of nitric oxide pathway in the relaxation response induced by E-c...
Veras, Robson Cavalcante; Rodrigues, Karoline Gomes; Fernandes, Maria do Carmo de Alustau; Gonçalves, Islania Giselia AlbuquerqueTexto completo: acesso restrito. p. 58–66; Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2014-05-29T12:42:22Z No. of bitstreams: 1 00005344-201307000-00008.pdf: 336437 bytes, checksum: 157830b0d31342a7c9eddd5be4db874c (MD5); Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2014-10-10T15:13:34Z (GMT) No. of bitstreams: 1 00005344-201307000-00008.pdf: 336437 bytes, checksum: 1578...