Supercritical fluid technology has been applied in the food area for processing and preserving food products and/or monitoring the food quality, with known advantages. The main solvent used at supercritical conditions for food applications is carbon dioxide. Some examples are presented, from the traditional decaffeination of coffee up to the micronization of vanilla, passing through innovative processes such as...
In Portugal,the pinewood nematode (PWN), Bursaphelenchus xylophilus, has been affecting Pinus pinaster, leading to economic and ecological losses, while P. pinea is a less susceptible species. The main goal of this study was to assess volatile composition of PWN-infected P. pinaster, and both non-infected P. pinaster and P. pinea branches, by using supercritical carbon dioxide extraction compared with solidphas...
A comparative pharmacokinetic study was conducted in rats after intratracheal aerosolization of levofloxacin, as a solution, as immediate-release chitosan microspheres or as sustained-release PLGA microspheres. A pharmacokinetic model was constructed to model levofloxacin concentrations both in plasma and in the lung epithelial lining fluid (ELF). The plasma and ELF experimental concentration profiles versus ti...
The aim of this work was the development of innovative levofloxacin-loaded swellable microspheres (MS) for the dry aerosol therapy of pulmonary chronicPseudomonas aeruginosainfections in Cystic Fibrosis patients. In a first step, a factorial design was applied to optimize formulations of chitosan-based MS with glutaraldehyde as crosslinker. After optimization, other crosslinkers (genipin, glutaric acid and glyc...
Cystic fibrosis (CF) is a complex inherited disease which affects many organs, including the pancreas and liver, gastrointestinal tract and reproductive system, sweat glands and, particularly, the respiratory system. Pseudomonas aeruginosa is the main cause of chronic airway infection. In order to reduce morbidity and mortality due to lung infection by P. aeruginosa, aerosol antibiotics have been used to achiev...
The aim of the work described here was to find evidence for the influence of stroke length on the reciprocating wear of aluminium matrix composites. For this purpose, two kinds of tests were performed: reciprocating ball-on-plane geometry experiments to apply stroke in the millimetre range, and fretting tests to study the strokes in the micrometer scale. The relationships between the dissipated energy and the w...
The present work describes research conducted on the fretting behaviour of S 355 MC galvanised steel sheet. In order to study the influence of the normal load and the displacement effect, some of the specimens were galvanised by hot dipping and the rest were only polished before being tested. Fretting tests were carried out on a specially developed fretting rig prototype under [`]crossed-cylinders' contact geom...