5 documents found, page 1 of 1
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis thr...
Oliveira, Cláudia S. F.; Pereira, Helena Paula Fernandes; Alves, Sara Cristina Sequeira; Castro, Lisandra Marisa Flores; Baltazar, FátimaAcetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of the lysosomal protease cathepsin D (CatD), which has a well-established role in the mitochondrial apoptotic cascade...
Impact of mutated KRAS signalling on autophagy regulation in colorectal carcinoma
Alves, Sara Cristina SequeiraColorectal carcinoma (CRC) is the third most commonly diagnosed cancer worldwide and one of the most abundant causes of cancer related deaths. KRAS mutations ( KRASG13D, KRASG12D and KRASG12V) are frequent events in CRC, detected in about 30% to 50% of the clinical cases, and seem to play an important role in colon carcinogenesis. It is known that KRAS mutations are predictive biomarkers for resistance of CRC t...
What yeast can tell us about how cells commit suicide?
Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; Gerós, H.Multicellular organisms developed a complex system to balance cell proliferation and cell death in order to guarantee correct embryonic development and tissue homeostasis. Failure of cells to undergo programmed cell death (PCD) can potentially lead to severe diseases, including neural degeneration, autoimmunity and cancer. Identifying the molecules involved in PCD and understanding the regulation of the process...
Vacuole-mitochondrial crosstalk during apoptosis induced by acetic acid in yeast
Chaves, S. R.; Coutinho, Clara Pereira; Marques, Carolina; Rodrigues, Andreia; Salin, Bénédict; Alves, Sara Cristina Sequeira; Silva, Rui; Gerós, H.
Regulação da autofagia pelo KRAS de modo a compreender o seu papel no cancro hu...
Alves, Sara Cristina SequeiraA evasão à morte celular programada (MCP) é uma das características dos cancros humanos. O papel da autofagia no cancro não é bem compreendido. Dependendo do tipo e contexto celulares, a autofagia pode actuar como um mecanismo supressor de tumor, induzindo a MCP, ou como um processo de sobrevivência. A mutação oncogénica KRAS está entre os eventos mais frequentes no carcinoma colorectal (CCR), ocorrendo em cerc...