16 documents found, page 1 of 2
Anonymization Through Substitution: Words vs Sentences
Alves, V; Rolla, V; Alveira, J; Pissarra, D; Pereira, D; Curioso, I; Carreiro, V; Henrique Lopes CardosoAnonymization of clinical text is crucial to allow the sharing and disclosure of health records while safeguarding patient privacy. However, automated anonymization processes are still highly limited in healthcare practice, as these systems cannot assure the anonymization of all private information. This paper explores the application of a novel technique that guarantees the removal of all sensitive information...
Imipenem-Relebactam Susceptibility in Enterobacterales Isolates Recovered from ...
Hernández-García, M; García-Castillo, M; Bou, G; Cercenado, E; Delgado-Valverde, M; Oliver, A; Pitart, C; Rodríguez-Lozano, J; Tormo, NImipenem-relebactam is a novel β-lactam-β-lactamase inhibitor combination. We evaluated the in vitro activity of imipenem-relebactam and comparators against Enterobacterales clinical isolates recovered in 8 Spanish and 11 Portuguese intensive care units (ICUs) (SUPERIOR, 2016-2017; STEP, 2017-2018). Overall, 747 Enterobacterales isolates (378 Escherichia coli, 252 Klebsiella spp., 64 Enterobacter spp., and 53 o...
Confronting Ceftolozane-Tazobactam Susceptibility in Multidrug-Resistant Entero...
Hernández-García, M; García-Fernández, S; García-Castillo, M; Melo-Cristino, J; Pinto, M; Gonçalves, E; Alves, V; Costa, E; Ramalheira, E; Sancho, LCeftolozane-tazobactam (C/T) is frequently used for infections caused by multidrug-resistant (MDR)-Enterobacterales isolates. Whole-genome sequencing (WGS, Illumina-Hiseq 4000/NovaSeq 6000, OGC, UK) was used to study the population structure, the resistome and the virulome of C/T-susceptible and -resistant MDR Escherichia spp. (n=30) and Klebsiella spp. (n=78) isolates, recovered from lower respiratory, intra-a...
In Vitro Activity of Ceftolozane-Tazobactam Against Enterobacterales and Pseudo...
García-Fernández, S; García-Castillo, M; Melo-Cristino, J; Pinto, M; Gonçalves, E; Alves, V; Vieira, AR; Ramalheira, E; Sancho, L, et al.The STEP surveillance study was designed to increase knowledge about distribution of multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa in Portugal, focusing on the intensive care unit (ICU). Antimicrobial susceptibility of common agents was also evaluated and compared with that of one of the latest therapeutic introductions, ceftolozane-tazobactam (C/T). Clinical isolates of Enterobacterales...
In Vitro Activity of Ceftolozane-Tazobactam Against Enterobacterales and Pseudo...
García-Fernández, S; García-Castillo, M; Melo-Cristino, J; Pinto, M; Gonçalves, E; Alves, V; Vieira, AR; Ramalheira, E; Sancho, L; Diogo, J; Ferreira, RThe STEP surveillance study was designed to increase knowledge about distribution of multidrug-resistant (MDR) Enterobacterales and Pseudomonas aeruginosa in Portugal, focusing on the intensive care unit (ICU). Antimicrobial susceptibility of common agents was also evaluated and compared with that of one of the latest therapeutic introductions, ceftolozane-tazobactam (C/T). Clinical isolates of Enterobacterales...
Oxidative Stress Adaptation in Aggressive Prostate Cancer May Be Counteracted b...
Freitas, M; Baldeiras, I; Proença, T; Alves, V; Mota-Pinto, A; Sarmento-Ribeiro, AOxidative stress has been associated with prostate cancer development and progression due to an increase of reactive oxygen species (ROS). However, the mechanisms whereby ROS and the antioxidant system participate in cancer progression remain unclear. In order to clarify the influence of oxidative stress in prostate cancer progression, we performed this study in two human prostate cancer cell lines, PC3 and HPV...
Aging and asthma - changes in CD45RA, CD29 and CD95 T cells subsets
Todo-Bom, A; Mota-Pinto, A; Alves, V; Santos-Rosa, MBACKGROUND: Aging is associated with thymus involution leading to a reduction in naive T cells and to an accumulation of effector-memory cells. Apoptosis is a key mechanism to clear the immune system from activated and harmful cells. In asthma the stimulation of T cells by environmental antigens can decrease naive cells and sustain activated cells. The aim of this work was to evaluate the imbalance between CD45...
Regulatory T cells in elderly patients with asthma
Mota-Pinto, A; Todo-Bom, A; Alves, V; Santos, A; Santos-Rosa, MBACKGROUND: Airway walls in asthma present an accumulation of activated cells that determine bronchial structural changes and disease progression and severity. During the aging process, the immunoinflammatory response changes as a consequence of chronic antigenic stress. OBJECTIVE: To evaluate T-cell subsets with regulatory functions associated with asthma in elderly patients METHODS: A group of 153 individuals...
Asma: Reflexo da apoptose e de fenótipos de regulação
Todo-Bom, A; Mota-Pinto, A; Alves, V; Vale-Pereira, S; Chieira, S; Santos-Rosa, MA asma é uma doença inflamatória crónica das vias aéreas, e os linfócitos T desempenham um papel central na sua patogénese. Na inflamação alérgica quer os eosinófilos quer os linfócitos T podem ter um tempo de vida aumentado no local da inflamação, por redução da apoptose, mantendo-se activados. No pulmão encontra-se uma subclasse de linfócitos T que expressa receptor γδ. Estes linfócitos T γδ (TCRγδ) represent...
Apoptosis and asthma in the elderly
Todo-Bom, A; Mota-Pinto, A; Alves, V; Vale-Pereira, S; Santos-Rosa, MBACKGROUND: Asthma is a chronic inflammatory disorder of the airways. The persistence of airway inflammation depends on a decrease in apoptosis of T lymphocytes and eosinophils and survival of these activated cells. T lymphocytes expressing gamma delta receptors can be identified in human lungs and play an important role in immune defence against pathogens and in the regulation of chronic inflammation. Aging is...