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Biofunctional nanofibrous substrate for local TNF-capturing as a strategy to co...
Bacelo, Elisa; Alves da Silva, Marta; Cunha, Cristina; Faria, Susana; Carvalho, Agostinho; Reis, R. L.; Martins, Albino; Neves, Nuno M.Rheumatoid arthritis (RA) is an autoimmune disease that affects the synovial cavity of joints, and its pathogenesis is associated with an increased expression of pro-inflammatory cytokines, namely tumour necrosis factor-alpha (TNF-α). It has been clinically shown to have an adequate response to systemic administration of TNF-α inhibitors, although with many shortcomings. To overcome such limitations, the immobi...
Date: 2019
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Origin: RepositóriUM - Universidade do Minho