3 documents found, page 1 of 1
Will Spatial Transcriptomics Transform Pathology?
Cristovão, Miguel; Carmo-Fonseca, Maria; Alves-Vale, CatarinaSpatial transcriptomics (ST) is an emerging technology that maps gene expression directly onto tissue architecture. As it moves toward clinical adoption, ST is poised to become an integral tool in precision diagnostics. Here, we discuss its potential to complement and enhance traditional morphological assessment, reinforcing the pathologist’s central role in the molecular era.; A transcriptómica espacial (TE) é...
Expression of NORAD correlates with breast cancer aggressiveness and protects b...
Alves-Vale, Catarina; Capela, Ana Maria; Tavares-Marcos, Carlota; Domingues-Silva, Beatriz; Pereira, Bruno; Santos, Francisco; Gomes, Carla PereiraThe recently discovered human lncRNA NORAD is induced after DNA damage in a p53-dependent manner. It plays a critical role in the maintenance of genomic stability through interaction with Pumilio proteins, limiting the repression of their target mRNAs. Therefore, NORAD inactivation causes chromosomal instability and aneuploidy, which contributes to the accumulation of genetic abnormalities and tumorigenesis. NO...
An antisense transcript mediates MALAT1 response in human breast cancer
Gomes, Carla Pereira; Nobrega-Pereira, Sandrina; Domingues Silva, Ana Beatriz; Rebelo, Kenny; Alves-Vale, Catarina; Marinho, Sérgio; Carvalho, TâniaBackground: Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical applications during aging and disease. As example, targeting of MALAT1, a highly conserved lncRNA originally identified in metastatic non-small cell lung cancer, has shown promising results in cancer regr...