2 documents found, page 1 of 1
Will Spatial Transcriptomics Transform Pathology?
Cristovão, Miguel; Carmo-Fonseca, Maria; Alves-Vale, CatarinaSpatial transcriptomics (ST) is an emerging technology that maps gene expression directly onto tissue architecture. As it moves toward clinical adoption, ST is poised to become an integral tool in precision diagnostics. Here, we discuss its potential to complement and enhance traditional morphological assessment, reinforcing the pathologist’s central role in the molecular era.; A transcriptómica espacial (TE) é...
An antisense transcript mediates MALAT1 response in human breast cancer
Gomes, Carla Pereira; Nobrega-Pereira, Sandrina; Domingues Silva, Ana Beatriz; Rebelo, Kenny; Alves-Vale, Catarina; Marinho, Sérgio; Carvalho, TâniaBackground: Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical applications during aging and disease. As example, targeting of MALAT1, a highly conserved lncRNA originally identified in metastatic non-small cell lung cancer, has shown promising results in cancer regr...