6 documents found, page 1 of 1
The influence of individual characteristics and non-respiratory diseases on blo...
Amaral, Rita; Jacinto, Tiago; Malinovschi, Andrei; Janson, Christer; Price, David; Fonseca, João A.; Alving, KjellBlood eosinophil (B-Eos) count is an emerging biomarker in the management of respiratory disease but determinants of B-Eos count besides respiratory disease are poorly described. Therefore, we aimed to evaluate the influence of non-respiratory diseases on B-Eos count, in comparison to the effect on two other biomarkers: fraction of exhaled nitric oxide (FeNO) and C-reactive protein (CRP), and to identify indivi...
Comparison of hypothesis- and data-driven asthma phenotypes in NHANES 2007–2012...
Amaral, Rita; Pereira, Ana M.; Jacinto, Tiago; Malinovschi, Andrei; Janson, Christer; Alving, Kjell; Fonseca, João A.Half of the adults with current asthma among the US National Health and Nutrition Examination Survey (NHANES) participants could be classified in more than one hypothesis-driven phenotype. A data-driven approach applied to the same subjects may allow a more useful classification compared to the hypothesis-driven one. To compare previously defined hypothesis-driven with newly derived data-driven asthma phenotype...
Exhaled NO reference limits in a large population-based sample using the Lambda...
Jacinto, Tiago; Amaral, Rita; Malinovschi, Andrei; Janson, Christer; Fonseca, João; Alving, KjellAbsolute values are used in the interpretation of the fraction of exhaled nitric oxide (FeNO), but it has been suggested that equations to calculate reference values may be a practical and clinically useful approach. We hypothesize that the application of the Lambda-Mu-Sigma (LMS) method may improve FeNO reference equations and their interpretation. Our aims were to develop FeNO reference equations with the LMS...
Having concomitant asthma phenotypes is common and independently relates to poo...
Amaral, Rita; Fonseca, João A; Jacinto, Tiago; Pereira, Ana M; Malinovschi, Andrei; Janson, Christer; Alving, KjellEvidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Data from the National Health and Nutrition Examination Surveys (NHANES) 2007–2012 wer...
Having concomitant asthma phenotypes is common and independently relates to poo...
Amaral, Rita; Fonseca, João A.; Jacinto, Tiago; Pereira, Ana M.; Malinovschi, Andrei; Janson, Christer; Alving, KjellEvidence for distinct asthma phenotypes and their overlap is becoming increasingly relevant to identify personalized and targeted therapeutic strategies. In this study, we aimed to describe the overlap of five commonly reported asthma phenotypes in US adults with current asthma and assess its association with asthma outcomes. Data from the National Health and Nutrition Examination Surveys (NHANES) 2007–2012 wer...
Differential effect of cigarette smoke exposure on exhaled nitric oxide and blo...
Jacinto, Tiago; Malinovschi, Andrei; Janson, Christer; Fonseca, João; Alving, KjellTobacco smoking affects both the fraction of exhaled nitric oxide (FeNO) and blood eosinophil (B-Eos) count, two clinically useful biomarkers in respiratory disease that represent local and systemic type-2 inflammation, respectively. We aimed to study the influence of objectively measured smoke exposure on FeNO and B-Eos in a large population of subjects with and without asthma. Methods: We utilized the US Nati...