299 documents found, page 1 of 30
Abordagem da obesidade infantil através do Objetivo de Desenvolvimento Sustentá...
Rito, Ana; Gaspar, Marta; Alvito, Paula; Bento, Alexandra; Santos, Cristina AbreuA obesidade infantil constitui um dos maiores desafios de saúde pública do século XXI e representa uma ameaça significativa para o cumprimento do Objetivo de Desenvolvimento Sustentável 3 (ODS 3) – Saúde e Bem-Estar, definido pela Agenda 2030 das Nações Unidas. Este artigo analisa criticamente a relação entre a obesidade infantil e o ODS3, com especial enfoque no papel desempenhado pelo Instituto Nacional de Sa...
Towards safer edible insects: assessing contaminant bioaccumulation and depurat...
Cardoso, Diogo N.; Alvito, Paula; de Boevre, Marthe; Silva, Ana Rita; Pinto, José; Rodrigues, Ana; Prodana, Marija; Silva, Patricia; Mostafaie, AmidThe integration of insects into sustainable food and feed chains demands a robust evaluation of their capacity to accumulate and eliminate contaminants. Understanding these dynamics is fundamental to ensuring consumer safety and supporting the development of regulatory standards for insect-derived products. This study assessed the bioaccumulation and depuration kinetics of metal(loid)s (As, Cd, Pb) and mycotoxi...
Intestinal Permeability Studies using a more realistic barrier: performance of ...
Figueira, Carolina; Gravato, Carlos; Alvito, PaulaThe intestinal barrier, essential for overall health, can have its permeability affected by certain food compounds and additives. Among various models, in vitro cellular monolayers are the most commonly used to study this process. Among these, Caco-2 cells—representing enterocytes—are commonly used, though they lack complexity to mimic some properties of the intestinal barrier. This limitation can be overwhelme...
Ciguatera toxins, a potential health risk emerging in Europe: overview of progr...
Alvito, Paula; Gago-Martínez, AnaCiguatera Poisoning (CP) is considered an emerging risk of concern in several places worldwide. The risk of CP in Europe is currently being investigated, and important advantages have been achieved under two EuroCigua projects, which allowed the characterization of Caribbean Ciguatoxins as the main responsible for the contamination in the European Coastal areas investigated. Important challenges and limitations...
Determinantes Ambientais e Saúde Humana
Alvito, Paula; Fórum da Energia e ClimaO episódio 21 do programa Hora de Agir, dedicado ao tema "Determinantes Ambientais e Saúde Humana" (II), tendo o INSA integrado este episódio com uma participação do DAN sobre a ocorrência de contaminantes químicos em alimentos, as micotoxinas, metabolitos secundários produzidos por fungos, que se encontram maioritariamente em cereais e que provocam problemas de saúde a nível reprodutor, neurotóxico, gastrointe...
ODS 3 das Nações Unidas - Garantir Saúde e Bem-estar Para Todos até 2030 (II)
Alvito, Paula; Fórum Energia e ClimaO episódio 19 do programa Hora de Agir, dedicado ao tema "ODS 3 das Nações Unidas - Garantir Saúde e Bem-estar Para Todos até 2030" (II). Foram abordados outras formas de poluição, também elas muito nocivas, como a poluição sonora, a poluição química e os microplásticos que já começaram a aparecer nos alimentos que ingerimos e também no ar que respiramos. O INSA contribuiu com uma participação do Departamento d...
Exposure to mycotoxins in the Portuguese adult population
Maris, Elias; Namorado, Sónia; Chen, A.; Pero-Gason, Roger; De Boevre, Marthe; De Saeger, Sarah; Silva, Maria João; Alvito, PaulaMycotoxins are toxic fungal metabolites commonly found in food, posing health risks such as immunosuppression, carcinogenicity, and endocrine disruption. Despite regulatory limits, chronic low-level exposure remains a concern. Understanding real-life exposure in populations is essential for effective risk assessment. This study aims to investigate mycotoxin exposure among young adults in Portugal, contributing ...
Tracking Mycotoxin Exposure in Portugal: New Insights and Key Determinants
Namorado, Sónia; Maris, Elias; Chen, A.; Pero-Gascon, Roger; de Boevre, Marthe; De Saeger, Sarah; Silva, Maria João; Alvito, PaulaHuman biomonitoring (HBM) is a vital tool for assessing exposure to environmental chemicals. Mycotoxins have been associated with various adverse health effects, including estrogenic, immunotoxic, nephrotoxic, and teratogenic outcomes. In this presentation an overview of two recent HBM studies on multiple mycotoxins exposure biomarkers conducted in Portugal will be given. The first study analyzed 37 mycotoxin b...
Ingested titanium dioxide nanomaterials: new approach to investigate intestinal...
Ventura, Célia; Rolo, Dora; Gramacho, Ana C.; Vieira, Adriana; Roque, Rossana; Valente, Ana; Vital, Nádia; Pinto, Fátima; Alvito, PaulaOral exposure to titanium dioxide nanomaterials (TiO2NMs) is due to their presence in food, food contact materials, medicines and cosmetics. The gastrointestinal tract(GIT) represents primary site of contact, that may result in systemic exposure, if biological barriers are surpassed. The INGESTnano project aimed to investigate nano-bio interactions at the cellular/molecular levels within the context of the inte...
Exposure assessment of the European adult population to deoxynivalenol
Namorado, Sónia; Martins, Carla; Ogura, Joana; Assunção, Ricardo; Vasco, Elsa; Appenzeller, Brice; I Halldorsson, Thorhallur; Janasik, BeataMycotoxins are natural toxins produced by fungi that may cause adverse health effects thus constituting a public health concern. Deoxynivalenol (DON), a mycotoxin affecting the immune system and causing intestinal disorders, was selected as a priority under the European Human Biomonitoring Initiative (HBM4EU). Urinary total DON levels (tDON) of 1270 participants from six countries were used to characterize the ...