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SYNTHESIS, CHARACTERIZATION, DFT MODELING AND IN VITRO ANTIMYCOBACTERIAL ACTIVI...

Paris Junior,José Alberto; Cavicchioli,Maurício; Machado,Rachel Temperani Amaral; Pavan,Fernando Rogério; Nakahata,Douglas Hideki; Corbi,Pedro Paulo

In the present work, a silver(I) complex with the antimycobacterial drug isoniazid (inh) is described. Elemental and thermogravimetric analyses confirmed a 1:1 metal:ligand ratio for the silver-isoniazid (Ag-inh) complex with molecular composition AgC6H7N3O·NO3. Infrared (IR) analysis suggests a bidentate coordination of isoniazid to silver by the nitrogen of the NH2 group and by the oxygen of the C=O group, an...

Date: 2021   |   Origin: Oasisbr
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