The risk factors for coronavirus disease 2019 (COVID-19) severity are still poorly understood. Considering the pivotal role of the gut microbiota on host immune and inflammatory functions, we investigated the association between changes in the gut microbiota composition and the clinical severity of COVID-19. We conducted a multicenter cross-sectional study prospectively enrolling 115 COVID-19 patients categoriz...
Alpha-1-antitrypsin deficiency (AATD) is a genetic autosomal codominant disorder caused by mutations in SERPINA1 gene. It is one of the most prevalent genetic disorders, although it remains underdiagnosed. Whereas at international level there are several areas of consensus on this disorder, in Portugal, inter-hospital heterogeneity in clinical practice and resources available have been adding difficulties in re...
Although the oncologic disease has a low incidence in children than in adults, it has a major complexity and impact , because children are the future. The objectives of this study are: To study the impact of a oncologic disease in diagnostic in children on their family. To study how family cooperate. The authors interviewed the family of children who were admit into a oncologic hospital. Some conclusions: The d...
Incidence or prevalence studies on cutaneous lesions in general populations are not available. The community observed by the authors (Freixo de Espada à Cinta, North-Eastern Portugal) is relatively closed. A pre-tested questionnaire for socio-demographic and clinical information was used and a physical observation was conducted in January and February 1994 by the Dermatology Team of Santo António General Hospit...
The authors, using the Cancer Registry data of S. Antonio General Hospital in Oporto, selected the cancer cases from 1981 to 1993. Distribution according to age, sex, topography and morphology is presented. Seven point nine percent of the 12,124 cases mentioned in the Registry were skin cancers (n = 883). They were mostly on the face (56.8%), trunk (11.7%) and scalp and neck (7.7%). As for the type of tumour, 4...
Data from the population based Cancer Registry of Vila Nova de Gaia for the 1981-1987 period are presented. Cancer is becoming a disease increasingly frequent in Portugal, causing progressively higher mortality rates. Population and geographic characteristics of Vila Nova de Gaia country is presented. Information sources of this Registry are hospitals, pathology labs, Health Authority files and death certificat...