Background: Long COVID (LC) is a post-infectious condition affecting millions worldwide, characterized by persistent multisystem symptoms. Females are disproportionately affected, reporting higher symptom burden, particularly neurocognitive and neurosensory complaints. While short-term immunopathology has been described, the long-term clinical course, immune dysregulation, and sex-specific underpinnings remain ...
Introduction - Obstructive Sleep Apnea Syndrome (OSAS) and Recurrent Tonsillitis (RA) are the main indications for performing tonsillectomy in children. Despite the growing knowledge in tissue immunology of palatine tonsils, the pathophysiology that leads to the development of OSAS or RA is not fully known. Objectives - Comparative immunophenotypic analysis of children with OSAS versus RA. The epidemiological s...
The intricate interplay between maternal immune response to SARS-CoV-2 and the transfer of protective factors to the fetus remains unclear. By analyzing mother-neonate dyads from second and third trimester SARS-CoV-2 infections, our study shows that neutralizing antibodies (NAbs) are infrequently detected in cord blood. We uncovered that this is due to impaired IgG-NAb placental transfer in symptomatic infectio...
RESUMO: A investigação é essencial para compreender o sistema imunitário e destrinçar os mecanismos de doença. No entanto, a maioria dos estudos realizados não consideram as diferenças sexuais como variável. No caso especifico das mulheres, estas desenvolvem uma resposta imunitária mais forte, o que contribui não só para a rápida eliminação de agentes patogénicos, mas também para um aumento da eficácia na vacin...
Copyright © 2021 Lopes, Henriques, Santos-Dias, Nunes-da-Silva, Gonçalves, de Sousa, Abdulghani, Eletério, Braga, Soares, Branco, Canhão and Rodrigues.; Background: In response to rapid global spread of the newly emerged coronavirus disease 2019 (COVID-19), universities transitioned to online learning and telework to decrease risks of inter-person contact. To help administrators respond to the COVID-19 pandemic...
Funding: This work was supported by FCT grants (PTDC/MECREU/29520/2017 to HS and CHRC UIDB/4923/2020, UIPD/4923/2020). JG, MJJ, and DAS are supported by FCT through /BD/128343/2017, PTDC/EGE-OGE/32573/2017, and PD/BD/137409/2018, respectively. The anti-SARSCoV-2 ELISA assay was developed within the context of Serology4COVID consortium, in which IBET (Instituto de Biologia Experimental e Tecnológica) produced an...
Seroprevalence studies are crucial both for estimating the prevalence of SARS-CoV-2 exposure and to provide a measure for the efficiency of the confinement measures. Portuguese universities were closed on March 16th 2020, when Portugal only registered 62 SARS-CoV-2 infection cases per million. We have validated a SARS-CoV-2 ELISA assay to a stabilized full-length spike protein using 216 pre-pandemic and 19 mole...
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