7 documents found, page 1 of 1
Silk sericin/chitosan supramolecular multilayered thin films as sustainable cyt...
Rosas, Miguel; Sousa, Cristiana F. V.; Pereira, Ana; Amaral, Adérito J. R.; Pesqueira, Tamagno; Patrício, Sónia G.; Fateixa, SaraSilk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encom...
Double‐interlinked colloidal gels for programable fabrication of supraparticle ...
Gonçalves, Leandro; Lavrador, Pedro; Amaral, Adérito J. R.; Ferreira, Luís P.; Gaspar, Vítor M.; Mano, João F.Engineering colloidal gel inks with suitable features for fabricating robust supraparticle architectures through 3D printing may overcome the challenges of precisely controlling nanoparticles spatial distribution across multiple scales. Herein, oppositely charged proteinaceous-polymeric nanoparticles are combined to generate multi-component colloidal gel (COGEL) inks for fabricating supraparticle volumetric arc...
A supramolecular injectable methacryloyl chitosan-tricine-based hydrogel with 3...
Ouro, Pedro M. S.; Costa, Dora C. S.; Amaral, Adérito J. R.; Mano, João F.Printable hydrogels have attracted significant attention as versatile, tunable, and spatiotemporally controlled biomaterials for tissue engineering (TE) applications. Several chitosan-based systems are reported presenting low or no solubility in aqueous solutions at physiological pH. Herein, a novel neutrally charged, biomimetic, injectable, and cytocompatible dual-crosslinked (DC) hydrogel system based on a do...
Self-supporting hyaluronic acid-functionalized G-quadruplex-based perfusable mu...
Sousa, Vera; Amaral, Adérito J. R.; Castanheira, Edgar J.; Marques, Igor; Rodrigues, João M. M.; Félix, Vítor; Borges, João; Mano, João F.Dynamic G-quadruplex supramolecular hydrogels have aroused great interest in a broad range of bioapplications. However, neither the development of native extracellular matrix (ECM)-derived natural biopolymer-functionalized G-quadruplex hydrogels nor their use to create perfusable self-supporting hydrogels has been explored to date, despite their intrinsic potential as carrier vehicles of therapeutic agents, or ...
Double network laminarin-boronic/alginate dynamic bioink for 3D bioprinting cel...
Amaral, Adérito J. R.; Gaspar, Vítor M.; Lavrador, Pedro; Mano, João F.The design of dynamically crosslinked hydrogel bioinks for three-dimensional (3D) bioprinting is emerging as a valuable strategy to advance the fabrication of mechanically tuneable cell-laden constructs for 3Din vitrodisease modelling and tissue engineering applications. Herein, a dynamic bioink comprising boronic acid-functionalised laminarin and alginate is explored for bioprinting 3D constructs under physiol...
Responsive laminarin-boronic acid self-healing hydrogels for biomedical applica...
Amaral, Adérito J. R.; Gaspar, Vítor M.; Mano, João F.The precise chemical modification of marine-derived biopolymers provides a unique opportunity for fabricating a toolbox of bioactive (bio)materials with modulated physicochemical and biological properties. Herein, the β-glucan laminarin was functionalized with phenylboronic acid (PBA) moieties that impart chemical reactivity toward diol-containing polymers via boronate esterification. The modification, which in...
Synthesis of bifunctional cyclic carbonates from CO2 catalysed by choline-based...
Amaral, Adérito J. R.; Coelho, Jorge F. J.; Serra, Arménio C.Easily prepared choline iodide is an active catalyst for the synthesis of cyclic carbonates through the coupling reaction of CO2 and epoxides using low pressure (1 MPa), moderate temperature (85 ºC) and green solvents (ethanol and propan-2-ol). The effects of reaction temperature, pressure, reaction time and amount of catalyst used were also investigated. The results showed moderate to high yields and excellent...