39 documents found, page 1 of 4
The effects of physiotherapy interventions in the treatment of genito-pelvic pa...
Silva, Patrícia; Amaral, Ana; Sousa Coutinho, Maria IsabelThe Diagnostic and Statistical Manual of Mental Disorders (1) identifies four specific types of female sexual dysfunction: female sexual interest/arousal disorder, orgasm disorder, genito-pelvic pain/penetration disorder, and substance or medication-induced sexual dysfunction. Physiotherapy seems to have a crucial role in the management of these dysfunctions, particularly in sexual pain disorders, offering a ra...
Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endome...
Amaral, Ana; Cebola, Nélio; Szóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Kordowitzki, Paweł; Skarzynski, Dariusz; Ferreira-Dias, GraçaMyeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloi...
Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endome...
Amaral, Ana; Cebola, Nélio; Szóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Kordowitzki, Paweł; Skarzynski, Dariusz; Ferreira-Dias, GraçaMyeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloi...
Efeitos da fisioterapia no tratamento das disfunções sexuais femininas: revisão...
Amaral, Ana; Silva, Patrícia; Coutinho, Maria IsabelIntrodução: As disfunções sexuais femininas abrangem diversas perturbações que causam alterações no desejo, na excitação, no orgasmo e/ou dor. A fisioterapia parece ter um papel crucial no tratamento destas disfunções, existindo diversas intervenções consoante as necessidades apresentadas. Objetivo: Estudar as intervenções fisioterapêuticas realizadas em mulheres com disfunção sexual e os seus efeitos na sintom...
Inhibition of Myeloperoxidase Pro-Fibrotic Effect by Noscapine in Equine Endome...
Amaral, Ana; Cebola, Nélio; Zóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Kordowitzki, Paweł; Skarzynski, Dariusz; Ferreira-Dias, GraçaMyeloperoxidase is an enzyme released by neutrophils when neutrophil extracellular traps (NETs) are formed. Besides myeloperoxidase activity against pathogens, it was also linked to many diseases, including inflammatory and fibrotic ones. Endometrosis is a fibrotic disease of the mare endometrium, with a large impact on their fertility, where myeloperoxidase was shown to induce fibrosis. Noscapine is an alkaloi...
Grupo de interesse em Biologia Molecular
Ropio, Joana; Valença, Andreia; Belas, Adriana; Amaral, Ana; Pires, Ana Elisabete; Marques, Cátia; Batista, Mariana; Serafim, Michelle Karen BrasilA biologia molecular é uma área da biologia que se centra na utilização de técnicas baseadas no estudo de DNA, RNA e proteínas. Esta é, também, uma área transversal a virtualmente todas as áreas de investigação científica na atualidade. O recentemente formado Grupo de Interesse em Biologia Molecular (GIBioM) da FMV da Universidade Lusófona tem por objectivo reunir docentes e investigadores com valências técnica...
Impact of the expressia platform on a child with autism spectrum disorder: Case...
Amaral, Ana; Machado, Beatriz Martins; Có, Filipe; Gil, HenriqueThis research work has as its theme the Impact of the Expressia platform on a Child with Autism Disorder. More and more importance has been given to intervention using technological support tools for children with Autism Spectrum Disorder (AEP). With this work, it is intended to contribute to the reinforcement of intervention intervention using the Expressia tool in the (AEP).. The methodological part of this w...
Enzymes present in neutrophil extracellular traps may stimulate the fibrogenic ...
Rebordão, Maria Rosa; Amaral, Ana; Fernandes, Carina; Silva, E; Lukasik, Karolina; Szóstek-Mioduchowska, Anna; Bravo, Pedro; Galvão, AntónioEndometrosis is a fibrotic disease in mare endometrium whose pathological mechanisms remain obscure. Prostaglandin (PG)F2α, despite modulating reproductive physiological processes, may also provoke local pathological collagen deposition (fibrogenesis). Neutrophil extracellular traps (NETs) released during inflammation have been linked to fibrogenesis in several tissues. We have previously shown that enzymes fou...
The inhibitory effect of noscapine on the in vitro cathepsin G-induced collagen...
Amaral, Ana; Fernandes, Carina; Szostek-Mioduchowska, Anna; Lukasik, Karolina; Rebordão, Maria Rosa; Pinto-Bravo, Pedro; Skarzynski, Dariusz JanABSTRACT - Cathepsin G (CAT) is a protease released by neutrophils when forming neutrophil extracellular traps that was already associated with inducing type I collagen (COL1) in equine endometrium in vitro. Endometrosis is a fibrotic condition mainly characterized by COL1 deposition in the equine endometrium. The objective was to evaluate if noscapine (an alkaloid for cough treatment with anti-neoplastic and a...
Noscapine acts as a protease inhibitor of in vitro elastase-induced collagen de...
Amaral, Ana; Fernandes, Carina; Szóstek-Mioduchowska, Anna; Rebordão, Maria Rosa; Skarzynski, Dariusz Jan; Ferreira-Dias, GraçaABSTRACT - Endometrosis is a reproductive pathology that is responsible for mare infertility. Our recent studies have focused on the involvement of neutrophil extracellular traps enzymes, such as elastase (ELA), in the development of equine endometrosis. Noscapine (NOSC) is an alkaloid derived from poppy opium with anticough, antistroke, anticancer, and antifibrotic properties. The present work investigates the...