MHC class I molecules regulate brain development and plasticity in mice and HLA class I molecules are associated with brain disorders in humans. We investigated the relationship between plasma-derived soluble human HLA class I molecules (sHLA class I), HLA class I serotypes and dementia. A cohort of HLA class I serotyped elderly subjects with no dementia/predementia (NpD, n = 28), or with dementia (D, n = 28) w...
This is a post-peer-review, pre-copyedit version of an article published in Psychiatric Quarterly. The final authenticated version is available online at: https://doi.org/10.1007/s11126-020-09867-7; The prevalence of neurodegenerative diseases has been significantly increasing in the last decades, and it is expected to continue to grow. These health disorders can impair patients’ decision-making capacity in hea...
O envelhecimento da população é um fenómeno a nível mundial que ocorre a um ritmo acelerado. O envelhecimento encontra-se associado a perdas em vários domínios, nomeadamente o cognitivo e o físico. A atividade física e o funcionamento cognitivo encontram-se relacionados, podendo ser promovidos de forma conjunta ou individual, através de diferentes estratégias que permitem melhorar a qualidade de vida ao longo d...