6 documents found, page 1 of 1
Building a Portuguese coalition for biodiversity genomics
Marques, João P.; Alves, Paulo C.; Amorim, Isabel R.; Lopes, Ricardo J.; Moura, Monica; Myers, Eugene; Sim-sim, Manuela; Sousa-Santos, CarlaThe diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes...
Building a Portuguese coalition for biodiversity genomics
Marques, João P.; Alves, Paulo C.; Amorim, Isabel R.; Lopes, Ricardo Jorge; Moura, Monica; Myers, Eugene; Sim-Sim, Maria; Sousa-Santos, CarlaThe diverse physiography of the Portuguese land and marine territory, spanning from continental Europe to the Atlantic archipelagos, has made it an important repository of biodiversity throughout the Pleistocene glacial cycles, leading to a remarkable diversity of species and ecosystems. This rich biodiversity is under threat from anthropogenic drivers, such as climate change, invasive species, land use changes...
KPC-3-producing Klebsiella pneumoniae sequence type 392 from a dog’s clinical i...
Moreira da Silva, Joana; Menezes, Juliana; Mendes, Gabriel; Santos Costa, Sofia; Caneiras, Catia; Poirel, Laurent; Amaral, Andreia J.; Pomba, ConstançaResistance to carbapenems in Enterobacterales poses a threat to health care systems worldwide since those infections are associated with high mortality and limited treatment options. The latest European reports show that some southern European countries are almost endemic for carbapenemase-producing Enterobacterales (CPEs). Mirroring the European tendency, Portugal has been observing a steady increase in the oc...
IsomiR_Window : a system for analyzing small‑RNA‑seq data in an integrative and...
Vasconcelos, Ana M.; Carmo, Maria Beatriz; Ferreira, Beatriz; Viegas, Inês; Gama‑Carvalho, Margarida; Ferreira, António; Amaral, Andreia J.Background: IsomiRs are miRNA variants that vary in length and/or sequence when compared to their canonical forms. These variants display differences in length and/or sequence, including additions or deletions of one or more nucleotides (nts) at the 5′ and/or 3′ end, internal editings or untemplated 3′ end additions. Most available tools for small RNA-seq data analysis do not allow the identification of isomiRs...
Autoimmunity and allergy control in adults submitted to complete thymectomy ear...
Silva, Susana L.; Albuquerque, Adriana; Amaral, Andreia J.; Li, Quan-Zhen; Mota, Catarina; Cheynier, Rémi; Victorino, Rui M. M.The contribution of the decline in thymic activity for the emergence of autoimmunity is still debatable. Immune-competent adults submitted to complete thymectomy early in life provide a unique model to address this question. We applied here strict criteria to identify adults lacking thymic activity based on sjTREC levels, to exclude thymic rebound and/or ectopic thymuses. In agreement, they featured severe naïv...
Quality assessment and control of tissue specific RNA-seq libraries of Drosophi...
Amaral, Andreia J.; Brito, Francisco; Chobanyan, Tamar; Yoshikawa, Seiko; Yokokura, Takakazu; Van Vactor, David; Gama-Carvalho, MargaridaRNA-sequencing (RNA-seq) is rapidly emerging as the technology of choice for whole-transcriptome studies. However, RNA-seq is not a bias free technique. It requires large amounts of RNA and library preparation can introduce multiple artifacts, compounded by problems from later stages in the process. Nevertheless, RNA-seq is increasingly used in multiple studies, including the characterization of tissue-specific...