17 documents found, page 1 of 2

An Exemestane Derivative, Oxymestane-D1, as a New Multi-Target Steroidal Aromat...

Around 70-85% of all breast cancer (BC) cases are estrogen receptor-positive (ER+). The third generation of aromatase inhibitors (AIs) is the first-line treatment option for these tumors. Despite their therapeutic success, they induce several side effects and resistance, which limits their efficacy. Thus, it is crucial to search for novel, safe and more effective anti-cancer molecules. Currently, multi-target d...

Gestão dos Procedimentos Anestésicos em Contexto de Pandemia COVID-19: Aspetos ...

Este novo contexto de pandemia COVID-19, obrigou a uma reorganização dos recursos humanos e materiais afetos à prestação de cuidados de saúde, para dar resposta à avaliação e tratamento dos doentes com COVID-19, mas também a uma readaptação na abordagem clínica dos doentes no Serviço Nacional de Saúde (SNS) de forma transversal, para que, em paralelo, fosse garantida a prestação de cuidados aos doentes com COVI...

Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC ac...

The increasing use of synthetic cannabinoids (SCBs) in recreational settings is becoming a new paradigm of drug abuse. Although SCBs effects mimic those of the Cannabis sativa plant, these drugs are frequently more potent and hazardous. It is known that endocannabinoid signalling plays a crucial role in diverse reproductive events such as placental development. Moreover, the negative impact of the phytocannabin...

Integrating QR codes in a blended context-oriented mobile Learning model: a pro...

Technologies are creating learning opportunities that challenge traditional educational institutions. Students use mobile technologies outside the classroom but aren’t allowed to use them inside. Learning through mobile devices, known in literature as mobile learning (m-learning), highlights the acquisition of context-oriented contents. One of the promising technologies to be used for this goal is a variant of ...

The postoperative venous thromboembolism (TREVO) study - risk and case mortalit...

INTRODUCTION AND OBJECTIVES: Venous thromboembolism, risk of which is increased in surgical patients, is a preventable cause of morbidity and death. The primary objective of this study was to estimate the incidence of symptomatic postoperative venous thromboembolism in adults at a tertiary university hospital, overall and by surgical specialty. The secondary objective was to analyze severity of and mortality fr...

Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a ne...

Autophagy has an essential role in neuronal homeostasis and its dysregulation has been recently linked to neurotoxic effects of a growing list of psychoactive drugs, including amphetamines. However, the role of autophagy in β-keto amphetamine (β-KA) designer drugs-induced neurotoxicity has hitherto not been investigated. In the present study, we show that two commonly abused cathinone derivatives, 3,4-methylene...

Role of autophagy, apoptosis and oxidative stress in the toxicity of β-keto amp...

In vitro toxicity of ß-keto amphetamines mechanistic studies in hepatic and neu...

Farmacologia clínica cardiovascular em Anestesiologia - Farmacologia da proteçã...

O progressivo envelhecimento da população nos países desenvolvidos originou uma elevada prevalência de doentes medicados com fármacos de ação cardiovascular. Os anestesiologistas devem conhecer as indicações e interações terapêuticas entre estes fármacos e os da anestesia. A evidência disponível permite falar de farmacologia da proteção miocárdica. As guidelines atuais seguem os estudos que apresentam melhores ...

Farmacologia clínica cardiovascular em anestesiologia - Farmacologia da proteçã...

O progressivo envelhecimento da população nos países desenvolvidos originou uma elevada prevalência de doentes medicados com fármacos de ação cardiovascular. Os anestesiologistas devem conhecer as indicações e interações terapêuticas entre estes fármacos e os da anestesia. A evidência disponível permite falar de farmacologia da proteção miocárdica. As guidelines atuais seguem os estudos que apresentam melhores ...