Introduction: Type 2 diabetes affects about 13.3% of the Portuguese population. Metformin was for many years considered first-line pharmacology in diabetes and is currently still recommended as such in diabetics without cardiorenal comorbidities. Up to 30% of diabetics on metformin have vitamin B12 deficiency, which can manifest as potentially irreversible neuropathy, mimicking diabetic neuropathy. Periodic dos...
Acute cerebellitis is a rare disease resulting from dysfunction of the cerebellum or its connections, with infectious or inflammatory causes, varied clinical manifestations, and evidence of predominantly cerebellar inflammation on magnetic resonance imaging (MRI). It belongs to the spectrum of acute post-infectious cerebellar ataxia, a self-limited disease whose therapeutic approach is individualized. Three cli...
Guillain-Barré syndrome (GBS) is an autoimmune disease of the peripheral nervous system that is clinically characterized by rapidly progressing and symmetric muscle weakness, loss (or decrease) of deep tendon reflexes and respiratory distress, leading in some cases to the need for artificial ventilation. This is a clinical diagnosis that can be supported by the integration of several results, coming from cerebr...
Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disease of the central nervous system which, when it begins before the age of 18, is defined as paediatric MS. Most common clinical presentations include long tract involvement, brainstem/cerebellum syndromes, optic neuritis and acute disseminated encephalomyelitis. Paediatric-onset MS typically has a more inflammatory-active cours...
Introduction: Multiple sclerosis (MS) is an inflammatory and demyelinating disorder of central nervous system that can be diagnosed in pediatric age (<18 years) in 3–5% of the cases. This early onset is associated with higher relapse rates and earlier progression to neurological disability. By using NEDA-3 (No Evidence of Disease Activity-3) criteria, we aimed to identify clinical predictors associated with abs...
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Introduction: Severe peri-intraventricular haemorrhage has been associated with higher mortality and neurodevelopmental impairment. The impact of peri-intraventricular haemorrhage alone (without white matter injury) remains controversial. The aim of this study was to evaluate the influence of severe peri-intraventricular haemorrhage, associated or not with cystic peri-ventricular leukomalacia, on mortality and ...
Soil amendment with biochar is being considered as a strategy for improving available soil water and nutrient content and, thereby, plant performance. Our aim was to investigate whether physiological, biochemical and morphological responses of Eucalyptus globulus to biochar amendment were dependent on watering regime. We conducted a randomized, 6-week greenhouse experiment with 5-month old eucalypt rooted cutti...
Considering the increasing use of Lithium (Li) and the necessity to fulfil this demand, labile Li occurrence in the environment will be enhanced. Thus, additional research is needed regarding the presence of this element in marine environment and its potential toxic impacts towards inhabiting wildlife. The aim of the present study was to evaluate Li toxicity based on the exposure of Mytilus galloprovincialis to...
A obesidade tem-se vindo a tornar um flagelo da sociedade moderna, com cada vez maior prevalência nas crianças e com repercussões nefastas quer relativamente à sua saúde, quer para a própria limitação e discriminação na prática desportiva, estando inclusive mais sujeitas ao bullying, o que poderá provocar consequências na autoestima e quebra do rendimento escolar (APCOI, 2014). Segundo dados do Sistema Europeu ...