6 documents found, page 1 of 1
Micro-RNAs differentially expressed in comparative analysis of sperm samples wi...
Silva, Ricardo Tomaz da; Gomes, Matheus de Souza; Fujimura, Patrícia Tiemi; Ueira-Vieira, Carlos; Amaral, Laurence Rodrigues do; Beletti, Marcelo EmílioInfertility or subfertility in bovine males may be related to spermatic microRNAs (miRNAs), whose function seems to be associated with the regulation of gene expression, degradation or storage of messenger RNAs (mRNAs) for later translation into early embryonic development. Thus, the purpose of this study was to identify differentially expressed miRNAs in semen samples from bulls (Bos taurus) with low and high ...
In silico analysis of plant microRNAs and their targets in public database of P...
Costa Filho, Ailton Pereira da; Cançado, Fernando Augusto Corrêa Queiroz; Alves, Tamires Caixeta; Espíndola, Foued Salmen; Amaral, Laurence Rodrigues doPost-traumatic stress disorder (PTSD) refers to simultaneous appearance of intrusions, avoidance, negative cognitions, and hyperarousal, triggered by traumatic events. It’s a psychiatric illness highly comorbid with depression whose roots are unknown, although gene expression profile has shown to be linked with environment, providing molecular tips about stress diseases. Mature miRNAs are small non-coding RNAs ...
Accomplishing the genotype-specific serodiagnosis of single and dual Trypanosom...
Alessio, Glaucia Diniz; Araújo, Fernanda Fortes de; Sales Júnior, Policarpo Ademar; Gomes, Matheus de Souza; Amaral, Laurence Rodrigues doThe methods currently available for genotype-specific diagnosis of T. cruzi infection still present relevant limitations, especially to identify mixed infection. In the present investigation, we have evaluated the performance of Chagas-Flow ATE-IgG2a test for early and late differential diagnosis of single and dual genotype-specific T. cruzi infections. Serum samples from Swiss mice at early and late stages of ...
Performance of TcI/TcVI/TcII Chagas-Flow ATE-IgG2a for universal and genotype-s...
Alessio, Glaucia Diniz; Araújo, Fernanda Fortes de; Côrtes, Denise Fonseca; Sales Júnior, Policarpo Ademar; Lima, Daniela CristinaDistinct Trypanosoma cruzi genotypes have been considered relevant for patient management and therapeutic response of Chagas disease. However, typing strategies for genotype- specific serodiagnosis of Chagas disease are still unavailable and requires standardization for practical application. In this study, an innovative TcI/TcVI/TcII Chagas Flow ATE-IgG2a technique was developed with applicability for universa...
Mineração de regras para classificação de oncogenes medidos por microarray util...
Amaral, Laurence Rodrigues doArtificial Intelligence techniques are increasing their role in the solution of biological problems. The present study use a Genetic Algorithm (GA) in the search for high level IF-THEN rules. This GA was applied to miner classification rules from a gene expression database named NCI60. This database was developed using cancer cells measured by microarray. The goal of this mining is the discovery of relations am...
Aplicando princípios de aprendizado de máquina na construção de um biocurador a...
Amaral, Laurence Rodrigues doNowadays, the amount of biological data available by universities, hospitals and research centers has increased exponentially due the use of bioinformatics, with the development of methods and advanced computational tools, and high-throughput techniques. Due to this significant increase in the amount of available data, new strategies for capture, storage and analysis of data are necessary. In this scenario, a n...