4 documents found, page 1 of 1
Novel yeast-based biosensor for environmental monitoring of tebuconazole
Mendes, Filipa; Miranda, Eduarda; Amaral, Leslie Ann Silva; Carvalho, Carla; Castro, Bruno B.; Sousa, Maria João; Chaves, Susana Alexandra RodriguesAbstract: Due to increasing demand for high and stable crop production, human populations are highly dependent on pesticide use for growing and storing food. Environmental monitoring of these agrochemicals is therefore of utmost importance, because of their collateral effects on ecosystem and human health. Even though most current-use analytical methods achieve low detection limits, they require procedures that...
A versatile yeast model identifies the pesticides cymoxanil and metalaxyl as ri...
Amaral, Leslie Ann Silva; Mendes, Filipa; Côrte-Real, Manuela; Rego, António MIguel Araújo; Outeiro, Tiago F.; Chaves, Susana R.Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of Lewy bodies, which predominantly consist of aggregated forms of the protein alpha-synuclein (aSyn). While these aggregates are a pathological hallmark of PD, the etiology of most cases remains elusive. Although environmental risk factors have been identified, such as the pesticides diel...
Lactate Induces Cisplatin Resistance in S. cerevisiae through a Rad4p-Dependent...
Amaral, Leslie Ann Silva; Mendes, Filipa; Côrte-Real, Manuela; Sousa, Maria João; Chaves, Susana Alexandra RodriguesCisplatin is a widely used antineoplastic agent that has DNA as the main target, though cellular resistance hampers its therapeutic efficacy. An emerging hallmark of cancer cells is their altered metabolism, characterized by increased glycolysis even under aerobic conditions, with increased lactate production (known as the Warburg effect). Although this altered metabolism often results in increased resistance t...
The role of metabolism in the sensitivity of Saccharomyces cerevisiae to the an...
Amaral, Leslie Ann SilvaDissertação de mestrado em Genética Molecular; Cisplatin is a chemotherapeutic drug that can generate unrepairable DNA damage in rapidly proliferating cells, thus inducing a permanent cell cycle arrest or cell death. Currently, it is used in the treatment of patients with testicular, ovarian, head and neck, colorectal, bladder and lung cancers. There is accumulating evidence concerning cisplatin side effects, b...