12 documents found, page 1 of 2
Evaluation of the biocompatibility and skin hydration potential of vitamin E-lo...
Vaz, S.; Silva, R.; Amaral, M.H.; Martins, E.; Lobo, J.M. Sousa; Silva, Ana CatarinaLipid-based nanosystems, such as nanostructured lipid carriers (NLC) and nanoemulsions (NE) have been described as promising alternatives to conventional formulations for increase skin hydration. Besides, these systems have been used as efficient vehicles for lipophilic molecules that improve skin properties (e.g. vitamin E). In this study, we performed comparative investigations between hydrogels formulations ...
Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and an...
Costa, C.; Moreira, J.N.; Amaral, M.H.; Lobo, J.M. Sousa; Silva, Ana CatarinaEpileptic seizures and anxiety crisis are severe conditions that require fast and effective treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited brain bioavailability, following oral, intravenous or rectal administration. This relates with the limited extent at which these drugs bypass the blood brain barrier (BBB). Thereby, the development of strategies that significantl...
Intranasal lipid nanoparticles for the treatment of neurodegenerative diseases
Cunha, S.; Almeida, H.; Amaral, M.H.; Lobo, J.M. Sousa; Silva, Ana CatarinaBackground: treatments for neurodegenerative diseases are challenging, due to the absence of fully effective medicines. One of the major problems associated to these is the occurrence of non-targeting events, which leads to adverse effects and requires frequent dose administration. Methods: Researches have been performed to develop new drug delivery systems administrated by alternative routes. For example, the ...
Formulations based on Solid Lipid Nanoparticles (SLN) and Nanostructured Lipid ...
Garcês, A.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, Ana CatarinaCutaneous use of lipid nanoparticles (solid lipid nanoparticles, SLN and nanostructured lipid carriers, NLC) has been showing promising results. These systems consist of low viscosity aqueous dispersions, being usually employed by means of semi-solid formulations with adequate consistency for skin application. This review addresses the cutaneous use of lipid nanoparticles for therapeutic and cosmetic applicatio...
Characterization and biocompatibility evaluation of cutaneous formulations cont...
Eiras, F.; Amaral, M.H.; Silva, R.; Martins, E.; Lobo, J.M. Sousa; Silva, Ana CatarinaNanostructured lipid carriers (NLC) are well-known systems that show effectiveness to improve skin hydration, being suggested for cosmetic and dermatological use. Nonetheless, NLC dispersions present low viscosity, which is non-attractive for cutaneous application. To circumvent this drawback, the dispersions can be gelled or incorporated in semisolid systems, increasing the final formulation consistency. In th...
Scaffolds for bone regeneration: state of the art
Moreno, M.; Amaral, M.H.; Lobo, J.M. Sousa; Silva, Ana CatarinaNowadays, millions of people worldwide are affected by problems of bones and articulations. These conditions represent about a half of the chronic diseases developed in individuals over 50 years, leading to problems of prolonged pain and physical inability, which usually require surgery, where bone grafts or implants are used. Nonetheless, despite the success of these therapeutic solutions, some drawbacks have ...
Therapeutic strategies for Alzheimer's and Parkinson's Diseases by means of dru...
Cunha, S.; Amaral, M.H.; Lobo, J.M. Sousa; Silva, Ana CatarinaAlzheimer's and Parkinson's diseases are prevalent neurodegenerative disorders worldwide, which are essentially related to aging. Within the remarkable era of nanomedicine, nowadays several delivery systems have been suggested to improve the treatment of these disorders, namely, liposomes, micelles, nanoparticles (polymeric, lipid, metallic and inorganic), exosomes, dendrimers and fullerenes. The advantage that...
Delivery systems for biopharmaceuticals. Part II: liposomes, micelles, microemu...
Silva, Ana Catarina; Lopes, Carla Martins; Lobo, J.M. Sousa; Amaral, M.H.Biopharmaceuticals are a generation of drugs that include peptides, proteins, nucleic acids and cell products. According to their particular molecular characteristics (e.g. high molecular size, susceptibility to enzymatic activity), these products present some limitations for administration and usually parenteral routes are the only option. To avoid these limitations, different colloidal carriers (e.g. liposome...
Lipid nanoparticles for the delivery of biopharmaceuticals
Silva, Ana Catarina; Amaral, M.H.; Lobo, J.M. Sousa; Lopes, Carla MartinsBiopharmaceuticals comprise therapeutic protein-based, nucleic acids and cell-based products. According to their therapeutic success, the clinical use of these products has been growing. Therefore, the development of efficient biopharmaceuticals delivery systems, which overcome their limitations for administration, remains an excellent prospect for pharmaceutical technologists. In this area, lipid nanoparticles...
Delivery systems for biopharmaceuticals. Part I: nanoparticles and microparticles
Silva, Ana Catarina; Lopes, Carla Martins; Lobo, J.M. Sousa; Amaral, M.H.Pharmaceutical biotechnology has been showing therapeutic success never achieved with conventional drug molecules. Therefore, biopharmaceutical products are currently well-established in clinic and the development of new ones is expected. These products comprise mainly therapeutic proteins, although nucleic acids and cells are also included. However, according to their sensitive molecular structures, the effici...