26 documents found, page 1 of 3

Silver nanoparticles for the management of neurological diseases

Thermo‐Responsive Microemulsions Containing Deep Eutectic‐Based Antibiotic Form...

The rise of antibiotic resistant strains, as methicillin-resistant Staphylococcus aureus (MRSA), challenges the current treatment of infections. In the case of ocular infections, antibiotic eye drops are commonly prescribed. However, their efficacy is usually compromised by the low viscosity of these formulations and the eye drainage. To overcome these drawbacks, deep eutectic solvent (DES)-based microemulsions...

Acne vulgaris topical therapies: application of probiotics as a new prevention ...

The skin microbiome is an essential barrier for preventing the invasion of pathogens and regulating the immune responses. When this barrier is disrupted, several dermatoses, including acne vulgaris, may arise. Most people will experience acne starting at the onset of puberty and continuing into adolescence; a significant percentage of those individuals continue to suffer from it into adulthood. Although common,...

Surface-modified lipid nanocarriers for crossing the blood-brain barrier (BBB):...

The blood-brain barrier (BBB) restricts the access of therapeutic agents to the brain, complicating the treatment of neurological diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), glioma, etc. To overcome this limitation and improve drug delivery to the central nervous system (CNS), the potential of nanocarriers, including lipid-based nanosystems, has been explored. ...

Riluzole-loaded lipid nanoparticles for brain delivery: preparation, optimizati...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, with a median survival of only 2 to 4 years. Riluzole, a drug commonly used in the management of ALS, has a low aqueous solubility and limited bioavailability. ALS treatment is also hindered by the presence of the blood–brain barrier (BBB) that preserves the delicate homeostasis of the cerebral milieu, isolating it and making brain drug d...

Thermo-responsive microemulsions containing deep eutectic-based antibiotic form...

The rise of antibiotic resistant strains, as methicillin-resistant Staphylococcus aureus (MRSA), challenges the current treatment of infections. In the case of ocular infections, antibiotic eye drops are commonly prescribed. However, their efficacy is usually compromised by the low viscosity of these formulations and the eye drainage. To overcome these drawbacks, deep eutectic solvent (DES)-based microemulsions...

Permeability assay and inflammatory marker quantification of lactoferrin functi...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a survival rate of 3 to 5 years from the onset of symptoms. ALS treatment is compromised by the existence of the blood-brain barrier (BBB), which restricts the access of promising biopharmaceutics to the brain, including riluzole, a drug commonly used to treat ALS. To circumvent the BBB and improve the drug brain targeting, nanosystems such...

Formulation, characterization, and cytotoxicity evaluation of lactoferrin funct...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...

Formulation, Characterization, and Cytotoxicity Evaluation of Lactoferrin Funct...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a very poor prognosis. Its treatment is hindered by a lack of new therapeutic alternatives and the existence of the blood–brain barrier (BBB), which restricts the access of drugs commonly used in ALS, such as riluzole, to the brain. To overcome these limitations and increase brain targeting, riluzole-loaded nanostructured lipid carriers (NL...

Preparações oftálmicas – novas estratégias para a promoção da biodisponibilidade

As preparações oftálmicas apresentam como principal vantagem o facto de poderem ser facilmente administradas pelo paciente. No entanto, estas preparações apresentam várias desvantagens, entre as quais se destaca o tempo de residência diminuto da formulação na superfície do globo ocular, o que condiciona a eficácia do fármaco veiculado. Desta forma, existem diversas estratégias que podem ser adotadas para aument...