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In Silico, In Vitro and In Vivo Toxicological Assessment of BPP-BrachyNH2, A Va...

Arcanjo, Daniel D. R.; Mafud, Ana Carolina; Vasconcelos, Andreanne G.; Silva-Filho, José Couras da; Amaral, Maurício P. M.; Brito, Lucas M.

BPP-BrachyNH2 is a proline-rich oligopeptide (PRO) firstly identified in skin secretion of the frog Brachycephalus ephippium, which possess in vitro inhibitory activity of angiotensin-I converting enzyme (ACE) and endothelium-dependent vasorelaxant activity. Considering its potential application in the treatment of cardiovascular diseases, the present work assessed the toxicological profile of the BPP-BrachyNH2...

Date: 2016   |   Origin: Repositório Científico do Instituto Politécnico do Porto
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