78 documents found, page 1 of 8
Chitosan nanoparticles for enhanced immune response and delivery of multi-epito...
Amaral, Rita; Concha, Tomás; Vítor, Jorge; Almeida, António J.; Calado, Cecília; Diogo Gonçalves, Lídia MariaHelicobacter pylori is the leading cause of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoma. Due to the emerging problems with antibiotic treatment against H. pylori in clinical practice, H. pylori vaccination has gained more interest. Oral immunization is considered a promising approach for preventing initial colonization of this bacterium in the gastrointestinal tract,...
Automated Adjustment of the Fraction of Inspired Oxygen (FiO2) and the Time Spe...
Rocha, Gustavo; Soares, Paulo; Flor-de-Lima, Filipa; Amaral, RitaIntroduction: The challenge of maintaining normoxemia in preterm infants undergoing respiratory support and oxygen therapy has led to the development of closed-loop automatic control systems for FiO2. The aim of this study was to assess the effectiveness of these systems in maintaining SpO2 within a target range (90% - 94%) in preterm neonates receiving supplemental oxygen.Methods: We conducted a single-centre ...
Adherence to treatment in allergic rhinitis during the pollen season in Europe:...
Bousquet, Jean; Amaral, RitaAdherence to rhinitis treatment has been insufficiently assessed. We aimed to use data from the MASK-airmHealth app to assess adherence to oral antihistamines (OAH), intra-nasal corticosteroids (INCS) or azelastine-fluticasone inpatients with allergic rhinitis. We included regular European MASK-air users with self-reported allergic rhinitis and reporting at least 1 day of OAH,INCS or azelastine-fluticasone. We ...
Allergic rhinitis and work productivity: Preliminary analysis of data from the ...
Ferreira, Laura; Pinto, Bernardo Sousa; Alves, Sandra Maria; Amaral, Rita; Alves, Sandra Maria; Amaral, RitaAllergic rhinitis is a health condition more prevalent in developed countries that can impact the activities and quality of life of affected individuals1. Although its impact on work productivity is recognized2, there is still a need for a more detailed understanding and quantification. This cross-sectional observational study investigates the relationship between allergic rhinitis and work productivity, using ...
Concepts for the Development of Person-Centered, Digitally Enabled, Artificial ...
Bousquet, Jean; Schünemann, Holger; Sousa-Pinto, Bernardo; Zuberbier, Torsten; Togias, Alkis; Samoliński, Bolesław; Bedbrook, AnnaAbstract The traditional healthcare model is focused on diseases (medicine and natural science) and does not acknowledge patients' resources and abilities to be experts in their own lives based on their lived experiences. Improving healthcare safety, quality, and coordination, as well as quality of life, is an important aim in the care of patients with chronic conditions. Person-centered care needs to ensure th...
Concepts for the Development of Person-Centered, Digitally Enabled, Artificial ...
Bousquet, Jean; Amaral, Rita; Amaral, RitaThe traditional healthcare model is focused on diseases (medicine and natural science) and does not acknowledge patients’ resources and abilities to be experts in their own lives based on their lived experiences. Improving healthcare safety, quality, and coordination, as well as quality of life, is an important aim in the care of patients with chronic conditions. Person-centered care needs to ensure that people...
Patients' health care resources utilization and costs estimation across cardiov...
Gavina, Cristina; Borges, Alexandra; Afonso-Silva, Marta; Fortuna, Inês; Canelas-Pais, Mariana; Amaral, Rita; Costa, Inês; Seabra, Daniel"Atherosclerotic Cardiovascular Disease (ASCVD) is a global public health concern. This study aimed to estimate the healthcare resource utilization (HRU) and costs stratified by cardiovascular disease (CVD) risk categories using real-world evidence, in a regional population in Portugal. This is a retrospective observational study, using data from Electronic Health Records between 2017 and 2021. Patients aged≥40...
Validation of the Adult Asthma Epidemiological Score: a secondary analysis of E...
Laranjeira, Catarina; Jácome, Cristina; Amaral, Rita; Bernardo, Filipa; Correia-deSousa, Jaime; Fonseca, João A.; Amaral, RitaThe A2 score is an 8-question patient-reported outcome measure that has been validated for ruling in (score ≥4) and ruling out (score 0-1) asthma. However, this screening tool has been validated in a cohort similar to the derivation cohort used. This study aims to validate the predictive accuracy of the A2 score in a primary care population against general practitioner (GP) clinical assessment and to determine ...
Understanding beliefs about inhaled medication in patients with persistent asth...
Novais, Catarina; Cruz, Ana Margarida; Pereira, Ana Margarida; Almeida, Rute; Amaral, Rita; Fonseca, João Almeida; Jácome, CristinaIdentifying factors influencing adherence, such as patients’ beliefs about medication, is essential for effective asthma management. This study aims to assess and gain insight into the beliefs of patients with asthma regarding inhaled medication. This is a secondary analysis of the INSPIRERS studies. Patients aged ≥ 13 y.o., with persistent asthma and a prescription for inhaled controller were recruited from 60...
Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The ...
Sousa-Pinto, Bernardo; Schünemann, Holger J.; Sá-Sousa, Ana; Vieira, Rafael José; Amaral, Rita; Anto, Josep M.; Klimek, Ludger; Czarlewski, WienczyslawaIntroduction: Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK-air ®, these data have only been analyzed cross-sectionally, without considering the changes of symptoms over time. We analyzed data from MASK-air ® longitudinally, clustering weeks according to reported rhinitis symptoms. Methods: We analyzed MASK-air ® data, assessing the weeks fo...