Obesogenic environments such as Westernized diets, overnutrition, and exposure to glycation during gestation and lactation can alter peripheral neuroendocrine factors in offspring, predisposing for metabolic diseases in adulthood. Thus, we hypothesized that exposure to obesogenic environments during the perinatal period reprograms offspring energy balance mechanisms. Four rat obesogenic models were studied: mat...
Nutritional disturbances during the early postnatal period can have long-lasting effects on neurodevelopment and may be related to behavioural changes at adulthood. While such neuronal connection disruption can contribute to social and behaviour alterations, the dysregulation of the neuroendocrine pathways involved in nutrient-sensing balance may also cause such impairments, although the underlying mechanisms a...
Introduction – The estimate of relative renal function (RRF) through scintigraphy with dimercaptosuccinic acid labeled with Technetium-99 metastable (99mTc-DMSA) may be influenced by kidney depth (KD), due to attenuation by soft tissue surrounded kidneys. Considering that rarely this KD is known, several methods for attenuation correction (AC) have been developed, namely those using empirical formulae, such as ...
Oxidative stress is involved in the metabolic dysregulation of type 2 diabetes (DM2). Acrocomia aculeata (Aa) fruit pulp has been described for the treatment of several diseases, and recently we have proved that its leaves have phenolic compounds with a marked antioxidant effect. We aimed to assess whether they can improve metabolic, redox and vascular functions in DM2. Control Wistar (W-Ctrl) and non-obese typ...
Although fruit juices are a natural source of sugars, there is a controversy whether their sugar content has similar harmful effects as beverages' added-sugars. We aimed to study the role of fruit juice sugars in inducing overweight, hyperglycaemia, glycation and oxidative stress in normal and diabetic animal models. In diabetic Goto-Kakizaki (GK) rats, we compared the effects of four different fruit juices (4-...
Introdução – A estimativa da função renal relativa (FRR) através de cintigrafia renal (CR) com ácido dimercaptossuccínico marcado com tecnécio-99 metaestável (99mTc-DMSA) pode ser influenciada pela profundidade renal (PR), atendendo ao efeito de atenuação por parte dos tecidos moles que envolvem os rins. Dado que raramente é conhecida esta mesma PR, diferentes métodos de correção de atenuação (CA) foram desenvo...
A revisão bibliográfica realizada aponta para a necessidade de compreender a natureza e as características comunicativas da Pessoa com afasia e do cuidador, tendo em conta as implicações que daí poderão advir para a PBE. Com este trabalho pretende-se: a) identificar as dificuldades sentidas pelo cuidador no processo de comunicação com a Pessoa com afasia; b) identificar as dificuldades comunicativas apresentada...