29 documents found, page 1 of 3
Impact of cannabidiol on viability of normal and tumorigenic human kidney cells...
Sousa, D.; Amaro, F.; Araújo, A. M.; Carvalho, M.Background: Cannabidiol (CBD), the main non-psychotropic cannabinoid of Cannabis sativa, has several pharmacological actions with therapeutic potential, including antitumor effects [1]; however, its effect on renal cell carcinoma (RCC) is unknown. Considering that recent research suggests that cell culture conditions, particularly the presence of serum in culture medium, may modulate the cannabinoids' antitumor...
Children’s participation in early childhood education: A theoretical overview
Correia, N.; Aguiar, C.; Amaro, F.Children’s right to participate in all matters and decisions affecting them has gained recognition in society. Its promotion is recommended from an early age – namely, in early childhood education settings – and it is described as benefiting children, adults and the community in general. Given the complex and polysemic meaning of participation, different conceptualizations, models and perspectives have emerged....
PMBOK 6th meets 7th: How to link both guides in order to support project tailor...
Amaro, F.; Domingues, L.Project Management is evolving more rapidly than ever[1]. Driven by the progress in new technologies and the emergence of agile methodologies, organizations such as the Project Management Institute (PMI) reviewed their Project Management Standards to reflect on this phenomenon. In its latest edition, the Project Management Body Of Knowledge 7th[1] (PMBOK), gather the largest number of evolutionary [2] and a dis...
West Nile virus transmission potential in Portugal
Lourenço, J.; Barros, S.C.; Zé-Zé, L.; Damineli, D.S.C.; Giovanetti, M.; Osório, H.C.; Amaro, F.; Henriques, A.M.; Ramos, F.; Luís, T.; Duarte, M.D.It is unclear whether West Nile virus (WNV) circulates endemically in Portugal. Despite the country’s adequate climate for transmission, Portugal has only reported four human WNV infections so far. We performed a review of WNV-related data (1966–2020), explored mosquito (2016–2019) and land type distributions (1992–2019), and used climate data (1981–2019) to estimate WNV transmission suitability in Portugal. Se...
Molecular Identification and Ecology of Portuguese Wild-Caught Phlebotomine San...
Zé-Zé, L.; Amaro, F.; Osório, H.; Giovanetti, M.; Lourenço, J.; Alves, M.J.Phlebotomine sandflies are important vectors of Leishmania spp. and phleboviruses causing disease in animals and humans. Morphological identification of phlebotomine sandflies to the species level is challenging, requiring microscopical examination of the genitalia, which is demanding and time consuming. Molecular sandfly species identification can be a practical solution to save resources since it enables furt...
Phylogenetic Analysis of Massilia phlebovirus in Portugal
Amaro, F.; Zé-Zé, L.; Lourenço, J.; Giovanetti, M.; Becker, S.C.; Alves, M.J.In the last two decades, molecular surveys of arboviruses have enabled the identification of several new viruses, contributing to the knowledge of viral diversity and providing important epidemiological data regarding possible new emerging viruses. A combination of diagnostic assays, Illumina sequencing and phylogenetic inference are here used to characterize two new Massilia phlebovirus strains isolated from s...
Seasonal Dynamics and Spatial Distribution of Aedes albopictus (Diptera: Culici...
Osório, H.; Rocha, J.; Roquette, R.; Guerreiro, N.; Zé-Zé, L.; Amaro, F.; Silva, M.; Alves, M.J.Aedes albopictus is an invasive mosquito that has colonized several European countries as well as Portugal, where it was detected for the first time in 2017. To increase the knowledge of Ae. albopictus population dynamics, a survey was carried out in the municipality of Loulé, Algarve, a Southern temperate region of Portugal, throughout 2019, with Biogents Sentinel traps (BGS traps) and ovitraps. More than 19,0...
Carbidopa Alters Tryptophan Metabolism in Breast Cancer and Melanoma Cells Lead...
Duarte, D.; Amaro, F.; Silva, I.; Silva, D.; Fresco, P.; Oliveira, José Carlos; REGUENGO, HENRIQUE; Gonçalves, J.; Vale, N.Carbidopa is used for the treatment of Parkinson's disease (PD) as an inhibitor of DOPA decarboxylase, and PD patients taking carbidopa have a lower incidence of various tumors, except for breast cancer and melanoma. Recently, it was shown that carbidopa inhibits tryptophan-2,3-dioxygenase (TDO) and kynureninase enzymes. In the present study, the effect of carbidopa on the viability and metabolic profile of bre...
Children's right to participate in early childhood education settings: a system...
Correia, N.; Camilo, C.; Aguiar, C.; Amaro, F.Children's right to participate is considered pivotal for establishing a culture of democracy and citizenship. Although this is not a new concept, its application remains a challenge. This review aims to map peer-reviewed empirical research conducted on children's right to participate, in center-based early childhood education settings, from 1980 on. A systematic literature search was performed and 36 studies m...
The Application and Interpretation of IgG Avidity and IgA ELISA Tests to Charac...
Amaro, F.; Sánchez-Seco, M.P.; Vásquez, A.; Alves, M.J.; Zé-Zé, L.; Luz, M.T.; Minguito, T.; De La Fuente, J; De Ory, F.In the absence of viremia, the diagnostics of Zika virus (ZIKV) infections must rely on serologicaltechniques. InordertoimprovetheserologicaldiagnosisofZIKV,ZIKV-IgAandZIKV-IgG avidity assays were evaluated. Forty patients returning from ZIKV endemic areas, with confirmed or suspected ZIKV infections were studied. Samples were classified as early acute, acute and late acute according to the number of days post il...